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DCDC2 Antibody (Center) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession Q9UHG0
Clone Names 100528237
Peptide ID 100528237
Additional Information
Gene ID 51473
Other Names Doublecortin domain-containing protein 2, Protein RU2S, DCDC2, KIAA1154, RU2
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name DCDC2
Synonyms KIAA1154, RU2
Function Protein that plays a role in the inhibition of canonical Wnt signaling pathway (PubMed:25557784). May be involved in neuronal migration during development of the cerebral neocortex (By similarity). Involved in the control of ciliogenesis and ciliary length (PubMed:25601850, PubMed:27319779).
Cellular Location Cell projection, cilium Cytoplasm, cytoskeleton, cilium axoneme. Cell projection, kinocilium {ECO:0000250|UniProtKB:D3ZR10}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:D3ZR10}. Note=Localizes to the ciliary axoneme and to mitotic spindle fibers in a cell-cycle- dependent manner.
Tissue Location Ubiquitously expressed. In brain, highly expressed in the entorhinal cortex, inferior temporal cortex, medial temporal cortex, hypothalamus, amygdala and hippocampus (PubMed:10601354, PubMed:16278297). Expressed in liver by cholangiocytes, the epithelial cells of the bile ducts (at protein level) (PubMed:27319779).
Research Areas
Citations (0)

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Background

This gene encodes a protein with two doublecortin peptidedomains. This domain has been demonstrated to bind tubulin andenhance microtubule polymerization. Mutations in this gene havebeen associated with Reading Disability (RD), also referred to asdevelopmental dyslexia.

References

Couto, J.M., et al. Am. J. Med. Genet. B Neuropsychiatr. Genet. 153B (2), 447-462 (2010) :Meda, S.A., et al. Neuroimage (2009) In press :Couto, J.M., et al. Biol. Psychiatry 66(4):368-375(2009)Wilcke, A., et al. Ann Dyslexia 59(1):1-11(2009)Meda, S.A., et al. Brain Imaging Behav 2(1):21-26(2008)

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$ 80.00
Cat# BP16874c
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