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AP3B2 Antibody (N-term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession Q13367
Clone Names 100528267
Peptide ID 100528267
Additional Information
Gene ID 8120
Other Names AP-3 complex subunit beta-2, Adaptor protein complex AP-3 subunit beta-2, Adaptor-related protein complex 3 subunit beta-2, Beta-3B-adaptin, Clathrin assembly protein complex 3 beta-2 large chain, Neuron-specific vesicle coat protein beta-NAP, AP3B2
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name AP3B2
Function Subunit of non-clathrin- and clathrin-associated adaptor protein complex 3 (AP-3) that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. AP-3 appears to be involved in the sorting of a subset of transmembrane proteins targeted to lysosomes and lysosome-related organelles. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals.
Cellular Location Cytoplasmic vesicle, clathrin-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Golgi apparatus Note=Component of the coat surrounding the cytoplasmic face of coated vesicles located at the Golgi complex.
Tissue Location Expression is specific to nervous system. Expressed in nerve terminal and cell body, and is associated with nerve-terminal vesicles. Expression seen in Purkinje cells, cortical neurons, neuroectodermal tumors and graded in cerebral cortex (deeper layers exhibit stronger expression)
Research Areas
Citations (0)

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Adaptor protein-3 (AP3) is a heterotetrameric vesicle-coatprotein complex. Some AP3 subunits are ubiquitously expressed,whereas others are expressed exclusively in neurons. Theneuron-specific AP3 complex, which includes AP3B2, is thought toserve neuron-specific functions such as neurotransmitter release(Grabner et al., 2006 [PubMed 16788073]).


Nicolas, E., et al. Eur. J. Hum. Genet. 18(10):1107-1113(2010)Hashimoto, R., et al. Neurosci. Res. 65(1):113-115(2009)Chen, C., et al. DNA Seq. 18(3):165-168(2007)Grabner, C.P., et al. Proc. Natl. Acad. Sci. U.S.A. 103(26):10035-10040(2006)Dubois, T., et al. Biochem. Biophys. Res. Commun. 301(2):502-508(2003)

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$ 80.00
Cat# BP16877a
(40 western blots)
Availability: In Stock
Bulk Size
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