|Other Names||AP-3 complex subunit beta-2, Adaptor protein complex AP-3 subunit beta-2, Adaptor-related protein complex 3 subunit beta-2, Beta-3B-adaptin, Clathrin assembly protein complex 3 beta-2 large chain, Neuron-specific vesicle coat protein beta-NAP, AP3B2|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Subunit of non-clathrin- and clathrin-associated adaptor protein complex 3 (AP-3) that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. AP-3 appears to be involved in the sorting of a subset of transmembrane proteins targeted to lysosomes and lysosome-related organelles. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals.|
|Cellular Location||Cytoplasmic vesicle, clathrin-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Golgi apparatus Note=Component of the coat surrounding the cytoplasmic face of coated vesicles located at the Golgi complex.|
|Tissue Location||Expression is specific to nervous system. Expressed in nerve terminal and cell body, and is associated with nerve-terminal vesicles. Expression seen in Purkinje cells, cortical neurons, neuroectodermal tumors and graded in cerebral cortex (deeper layers exhibit stronger expression)|
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Adaptor protein-3 (AP3) is a heterotetrameric vesicle-coatprotein complex. Some AP3 subunits are ubiquitously expressed,whereas others are expressed exclusively in neurons. Theneuron-specific AP3 complex, which includes AP3B2, is thought toserve neuron-specific functions such as neurotransmitter release(Grabner et al., 2006 [PubMed 16788073]).
Nicolas, E., et al. Eur. J. Hum. Genet. 18(10):1107-1113(2010)Hashimoto, R., et al. Neurosci. Res. 65(1):113-115(2009)Chen, C., et al. DNA Seq. 18(3):165-168(2007)Grabner, C.P., et al. Proc. Natl. Acad. Sci. U.S.A. 103(26):10035-10040(2006)Dubois, T., et al. Biochem. Biophys. Res. Commun. 301(2):502-508(2003)
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