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PCSK4 Antibody (N-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q6UW60 |
|---|---|
| Clone Names | 100528271 |
| Gene ID | 54760 |
|---|---|
| Other Names | Proprotein convertase subtilisin/kexin type 4, 3421-, Proprotein convertase 4, PC4, PCSK4 {ECO:0000312|EMBL:AAH363541} |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | PCSK4 {ECO:0000312|EMBL:AAH36354.1} |
|---|---|
| Function | Proprotein convertase involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues (By similarity). In males, important for ADAM2 processing as well as other acrosomal proteins with roles in fertilization and critical for normal fertilization events such as sperm capacitation, acrosome reaction and binding of sperm to zona pellucida (By similarity). Also plays a role in female fertility, involved in the regulation of trophoblast migration and placental development, may be through the proteolytical processing and activation of proteins such as IGF2 (PubMed:16040806). May also participate in folliculogenesis in the ovaries (By similarity). |
| Cellular Location | Membrane; Single-pass membrane protein. Cytoplasmic vesicle, secretory vesicle, acrosome membrane {ECO:0000250|UniProtKB:P29121} |
| Tissue Location | Placenta.. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Proprotein convertases, including PCSK4, arecalcium-dependent serine proteases related to bacterial subtilisinsand to yeast kexin. These enzymes process precursor proteins totheir active forms by selective cleavage of the polypeptide atsites following paired basic amino acids. In mammals, this familycomprises PC1 (MIM 162150), PC2 (MIM 162151), PC4, PC5 (MIM600488), furin (FUR; MIM 136950), and PACE4 (MIM 167405).Substrates for these enzymes range from prohormones to precursorsfor growth factors to cell surface receptors and viral surfaceglycoproteins (Cao et al., 2001 [PubMed 11776387]).[supplied byOMIM].
References
Bailey, S.D., et al. Diabetes Care (2010) In press :Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)Batta, K., et al. J. Mol. Biol. 385(3):788-799(2009)Qiu, Q., et al. Proc. Natl. Acad. Sci. U.S.A. 102(31):11047-11052(2005)Clark, H.F., et al. Genome Res. 13(10):2265-2270(2003)
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