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PCSK4 Antibody (N-term) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession Q6UW60
Clone Names 100528271
Peptide ID 100528271
Additional Information
Gene ID 54760
Other Names Proprotein convertase subtilisin/kexin type 4, 3421-, Proprotein convertase 4, PC4, PCSK4 {ECO:0000312|EMBL:AAH363541}
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name PCSK4 {ECO:0000312|EMBL:AAH36354.1}
Function Proprotein convertase involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues (By similarity). In males, important for ADAM2 processing as well as other acrosomal proteins with roles in fertilization and critical for normal fertilization events such as sperm capacitation, acrosome reaction and binding of sperm to zona pellucida (By similarity). Plays also a role in female fertility, involved in the regulation of trophoblast migration and placental development, may be through the proteolytical processing and activation of proteins such as IGF2 (PubMed:16040806). May also participate in folliculogenesis in the ovaries (By similarity).
Cellular Location Membrane; Single-pass membrane protein. Cytoplasmic vesicle, secretory vesicle, acrosome membrane {ECO:0000250|UniProtKB:P29121}
Tissue Location Placenta..
Research Areas
Citations (0)

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Background

Proprotein convertases, including PCSK4, arecalcium-dependent serine proteases related to bacterial subtilisinsand to yeast kexin. These enzymes process precursor proteins totheir active forms by selective cleavage of the polypeptide atsites following paired basic amino acids. In mammals, this familycomprises PC1 (MIM 162150), PC2 (MIM 162151), PC4, PC5 (MIM600488), furin (FUR; MIM 136950), and PACE4 (MIM 167405).Substrates for these enzymes range from prohormones to precursorsfor growth factors to cell surface receptors and viral surfaceglycoproteins (Cao et al., 2001 [PubMed 11776387]).[supplied byOMIM].

References

Bailey, S.D., et al. Diabetes Care (2010) In press :Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)Batta, K., et al. J. Mol. Biol. 385(3):788-799(2009)Qiu, Q., et al. Proc. Natl. Acad. Sci. U.S.A. 102(31):11047-11052(2005)Clark, H.F., et al. Genome Res. 13(10):2265-2270(2003)

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$ 80.00
Cat# BP16878a
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