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WTAP Antibody (C-term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession Q15007
Clone Names 100528190
Peptide ID 100528190
Additional Information
Gene ID 9589
Other Names Pre-mRNA-splicing regulator WTAP, Female-lethal(2)D homolog, hFL(2)D, WT1-associated protein, Wilms tumor 1-associating protein, WTAP, KIAA0105
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms KIAA0105
Function Regulatory subunit of the WMM N6-methyltransferase complex, a multiprotein complex that mediates N6-methyladenosine (m6A) methylation of some adenosine residues of some mRNAs and plays a role in the efficiency of mRNA splicing, processing and mRNA stability. Required for accumulation of METTL3 and METTL14 to nuclear speckle (PubMed:24316715, PubMed:24407421, PubMed:24981863). Acts as a mRNA splicing regulator (PubMed:12444081). Regulates G2/M cell-cycle transition by binding to the 3' UTR of CCNA2, which enhances its stability (PubMed:17088532). Impairs WT1 DNA-binding ability and inhibits expression of WT1 target genes (PubMed:17095724).
Cellular Location Nucleus, nucleoplasm Nucleus speckle
Tissue Location Ubiquitously expressed.
Research Areas
Citations (0)

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The Wilms tumor suppressor gene WT1 appears to play a rolein both transcriptional and posttranscriptional regulation ofcertain cellular genes. This gene encodes a WT1-associatingprotein, which is a ubiquitously expressed nuclear protein. LikeWT1 protein, this protein is localized throughout the nucleoplasmas well as in speckles and partially colocalizes with splicingfactors. Alternative splicing of this gene results in threetranscript variants, two of which encode the same isoform.


Su, J., et al. Diabetes Res. Clin. Pract. 87(2):167-175(2010)Small, T.W., et al. J. Biol. Chem. 284(37):24684-24695(2009)Benyamin, B., et al. Am. J. Hum. Genet. 84(1):60-65(2009)Zhong, S., et al. Plant Cell 20(5):1278-1288(2008)Matsuoka, S., et al. Science 316(5828):1160-1166(2007)

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$ 80.00
Cat# BP16885b
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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