|Other Names||Pre-mRNA-splicing regulator WTAP, Female-lethal(2)D homolog, hFL(2)D, WT1-associated protein, Wilms tumor 1-associating protein, WTAP, KIAA0105|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Regulatory subunit of the WMM N6-methyltransferase complex, a multiprotein complex that mediates N6-methyladenosine (m6A) methylation of some adenosine residues of some mRNAs and plays a role in the efficiency of mRNA splicing, processing and mRNA stability. Required for accumulation of METTL3 and METTL14 to nuclear speckle (PubMed:24316715, PubMed:24407421, PubMed:24981863). Acts as a mRNA splicing regulator (PubMed:12444081). Regulates G2/M cell-cycle transition by binding to the 3' UTR of CCNA2, which enhances its stability (PubMed:17088532). Impairs WT1 DNA-binding ability and inhibits expression of WT1 target genes (PubMed:17095724).|
|Cellular Location||Nucleus, nucleoplasm Nucleus speckle|
|Tissue Location||Ubiquitously expressed.|
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Provided below are standard protocols that you may find useful for product applications.
The Wilms tumor suppressor gene WT1 appears to play a rolein both transcriptional and posttranscriptional regulation ofcertain cellular genes. This gene encodes a WT1-associatingprotein, which is a ubiquitously expressed nuclear protein. LikeWT1 protein, this protein is localized throughout the nucleoplasmas well as in speckles and partially colocalizes with splicingfactors. Alternative splicing of this gene results in threetranscript variants, two of which encode the same isoform.
Su, J., et al. Diabetes Res. Clin. Pract. 87(2):167-175(2010)Small, T.W., et al. J. Biol. Chem. 284(37):24684-24695(2009)Benyamin, B., et al. Am. J. Hum. Genet. 84(1):60-65(2009)Zhong, S., et al. Plant Cell 20(5):1278-1288(2008)Matsuoka, S., et al. Science 316(5828):1160-1166(2007)
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