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WTAP Antibody (C-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q15007 |
|---|---|
| Clone Names | 100528190 |
| Gene ID | 9589 |
|---|---|
| Other Names | Pre-mRNA-splicing regulator WTAP, Female-lethal(2)D homolog, hFL(2)D, WT1-associated protein, Wilms tumor 1-associating protein, WTAP, KIAA0105 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | WTAP {ECO:0000303|PubMed:11001926, ECO:0000312|HGNC:HGNC:16846} |
|---|---|
| Function | Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing (PubMed:29507755). Required for accumulation of METTL3 and METTL14 to nuclear speckle (PubMed:24316715, PubMed:24407421, PubMed:24981863). Acts as a mRNA splicing regulator (PubMed:12444081). Regulates G2/M cell-cycle transition by binding to the 3' UTR of CCNA2, which enhances its stability (PubMed:17088532). Impairs WT1 DNA-binding ability and inhibits expression of WT1 target genes (PubMed:17095724). |
| Cellular Location | Nucleus speckle. Nucleus, nucleoplasm. Cytoplasm {ECO:0000250|UniProtKB:Q9ER69}. Note=Mainly nuclear with some fraction located in the cytoplasm. ZC3H13 is required to anchor component of the MACOM subcomplex, such as VIRMA, in the nucleus {ECO:0000250|UniProtKB:Q9ER69} |
| Tissue Location | Ubiquitously expressed. |
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Provided below are standard protocols that you may find useful for product applications.
Background
The Wilms tumor suppressor gene WT1 appears to play a rolein both transcriptional and posttranscriptional regulation ofcertain cellular genes. This gene encodes a WT1-associatingprotein, which is a ubiquitously expressed nuclear protein. LikeWT1 protein, this protein is localized throughout the nucleoplasmas well as in speckles and partially colocalizes with splicingfactors. Alternative splicing of this gene results in threetranscript variants, two of which encode the same isoform.
References
Su, J., et al. Diabetes Res. Clin. Pract. 87(2):167-175(2010)Small, T.W., et al. J. Biol. Chem. 284(37):24684-24695(2009)Benyamin, B., et al. Am. J. Hum. Genet. 84(1):60-65(2009)Zhong, S., et al. Plant Cell 20(5):1278-1288(2008)Matsuoka, S., et al. Science 316(5828):1160-1166(2007)
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