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>   home   >   Products   >   Peptides   >   Blocking Peptides   >   NHLH1 Antibody (Center) Blocking Peptide   

NHLH1 Antibody (Center) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession Q02575
Clone Names 100406142
Peptide ID 100406142
Additional Information
Other Names Helix-loop-helix protein 1, HEN-1, Class A basic helix-loop-helix protein 35, bHLHa35, Nescient helix loop helix 1, NSCL-1, NHLH1, BHLHA35, HEN1
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name NHLH1
Synonyms BHLHA35, HEN1
Function May serve as DNA-binding protein and may be involved in the control of cell-type determination, possibly within the developing nervous system.
Cellular Location Nucleus {ECO:0000255|PROSITE- ProRule:PRU00981} EMBL; M97507; AAA58634.1; -; Genomic_DNA EMBL; BC013789; AAH13789.1; -; mRNA CCDS; CCDS1204.1; - PIR; B46167; A45075 RefSeq; NP_005589.1; NM_005598.3 UniGene; Hs.30956; - ProteinModelPortal; Q02575; - SMR; Q02575; - BioGrid; 110872; 9 IntAct; Q02575; 5 STRING; 9606.ENSP00000302189; - iPTMnet; Q02575; - PhosphoSitePlus; Q02575; - BioMuta; NHLH1; - DMDM; 399885; - PaxDb; Q02575; - PRIDE; Q02575; - ProteomicsDB; 58111; - DNASU; 4807; - Ensembl; ENST00000302101; ENSP00000302189; ENSG00000171786 GeneID; 4807; - KEGG; hsa:4807; - CTD; 4807; - DisGeNET; 4807; - EuPathDB; HostDB:ENSG00000171786.5; - GeneCards; NHLH1; - HGNC; HGNC:7817; NHLH1 HPA; CAB033854; - HPA; HPA017943; - MIM; 162360; gene neXtProt; NX_Q02575; - OpenTargets; ENSG00000171786; - PharmGKB; PA31619; - eggNOG; KOG4029; Eukaryota eggNOG; ENOG411227D; LUCA GeneTree; ENSGT00760000119097; - HOGENOM; HOG000016617; - HOVERGEN; HBG016345; - InParanoid; Q02575; - KO; K09075; - OMA; MMLNSDA; - PhylomeDB; Q02575; - SignaLink; Q02575; - SIGNOR; Q02575; - GeneWiki; NHLH1; - GenomeRNAi; 4807; - PRO; PR:Q02575; - Proteomes; UP000005640; Chromosome 1 Bgee; ENSG00000171786; - CleanEx; HS_NHLH1; - ExpressionAtlas; Q02575; baseline and differential Genevisible; Q02575; HS GO; GO:0005634; C:nucleus; IBA:GO_Central GO; GO:0046983; F:protein dimerization activity; IEA:InterPro GO; GO:0000977; F:RNA polymerase II regulatory region sequence-specific DNA binding; IDA:NTNU_SB GO; GO:0000981; F:RNA polymerase II transcription factor activity, sequence-specific DNA binding; ISA:NTNU_SB GO; GO:0001228; F:transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding; IDA:NTNU_SB GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW GO; GO:0007417; P:central nervous system development; TAS:ProtInc GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IDA:NTNU_SB CDD; cd00083; HLH; 1 Gene3D;; -; 1 InterPro; IPR011598; bHLH_dom InterPro; IPR036638; HLH_DNA-bd_sf Pfam; PF00010; HLH; 1 SMART; SM00353; HLH; 1 SUPFAM; SSF47459; SSF47459; 1 PROSITE; PS50888; BHLH; 1 2: Evidence at transcript level; Complete proteome; Developmental protein; Differentiation; DNA-binding; Nucleus; Reference proteome; Transcription; Transcription regulation CHAIN 1 133 Helix-loop-helix protein 1 /FTId=PRO_0000127197 DOMAIN 75 127 bHLH. {ECO:0000255|PROSITE- ProRule:PRU00981} COMPBIAS 66 71 Poly-Arg SEQUENCE 133 AA; 14618 MW; FE90B574BE16D2C6 CRC64; MMLNSDTMEL DLPPTHSETE SGFSDCGGGA GPDGAGPGGP GGGQARGPEP GEPGRKDLQH LSREERRRRR RATAKYRTAH ATRERIRVEA FNLAFAELRK LLPTLPPDKK LSKIEILRLA ICYISYLNHV LDV
Research Areas
Citations (0)

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The helix-loop-helix (HLH) proteins are a family ofputative transcription factors, some of which have been shown toplay an important role in growth and development of a wide varietyof tissues and species. Four members of this family have beenclearly implicated in tumorigenesis via their involvement inchromosomal translocations in lymphoid tumors: MYC (MIM 190080),LYL1 (MIM 151440), E2A (MIM 147141), and SCL (MIM 187040).[suppliedby OMIM].


Manetopoulos, C., et al. Biochem. Biophys. Res. Commun. 307(4):891-899(2003)Bao, J., et al. Development 127(2):425-435(2000)Lipkowitz, S., et al. J. Biol. Chem. 267(29):21065-21071(1992)Brown, L., et al. Proc. Natl. Acad. Sci. U.S.A. 89(18):8492-8496(1992)Begley, C.G., et al. Proc. Natl. Acad. Sci. U.S.A. 89(1):38-42(1992)

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$ 80.00
Cat# BP16897c
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