|Other Names||Dual specificity protein phosphatase 12, Dual specificity tyrosine phosphatase YVH1, DUSP12|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Dual specificity phosphatase; can dephosphorylate both phosphotyrosine and phosphoserine or phosphothreonine residues. Can dephosphorylate glucokinase (in vitro) (By similarity). Has phosphatase activity with the synthetic substrate 6,8-difluoro-4- methylumbelliferyl phosphate and other in vitro substrates (PubMed:10446167, PubMed:24531476).|
|Cellular Location||Nucleus. Cytoplasm, cytosol. Note=Primarily nuclear. Detected in a mesh-like pattern in the cytosol|
|Tissue Location||Ubiquitous, highest expression in spleen, testis, ovary, and peripheral blood leukocytes and lower expression in liver and lung|
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The protein encoded by this gene is a member of the dualspecificity protein phosphatase subfamily. These phosphatasesinactivate their target kinases by dephosphorylating both thephosphoserine/threonine and phosphotyrosine residues. Theynegatively regulate members of the mitogen-activated protein (MAP)kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which is associatedwith cellular proliferation and differentiation. Different membersof the family of dual specificity phosphatases show distinctsubstrate specificities for various MAP kinases, different tissuedistribution and subcellular localization, and different modes ofinducibility of their expression by extracellular stimuli. Thisgene product is the human ortholog of the Saccharomyces cerevisiaeYVH1 protein tyrosine phosphatase. It is localized predominantly inthe nucleus, and is novel in that it contains, and is regulated bya zinc finger domain.
Biernacki, M.A., et al. Cancer Res. 70(3):906-915(2010)Bonham, C.A., et al. J. Biol. Chem. 284(34):22853-22864(2009)Sharda, P.R., et al. Biochem. J. 418(2):391-401(2009)Gao, F., et al. Zhonghua Yi Xue Za Zhi 88(32):2250-2253(2008)Hasstedt, S.J., et al. Ann. Hum. Genet. 72 (PT 2), 163-169 (2008) :
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