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SEPX1 Antibody (Center) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q9NZV6 |
|---|---|
| Clone Names | 100603042 |
| Gene ID | 51734 |
|---|---|
| Other Names | Methionine-R-sulfoxide reductase B1, MsrB1, 184-, Selenoprotein X, SelX, MSRB1, SEPX1 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | MSRB1 |
|---|---|
| Synonyms | SEPX1 |
| Function | Methionine-sulfoxide reductase that specifically reduces methionine (R)-sulfoxide back to methionine. While in many cases, methionine oxidation is the result of random oxidation following oxidative stress, methionine oxidation is also a post-translational modification that takes place on specific residue. Acts as a regulator of actin assembly by reducing methionine (R)-sulfoxide mediated by MICALs (MICAL1, MICAL2 or MICAL3) on actin, thereby promoting filament repolymerization. Plays a role in innate immunity by reducing oxidized actin, leading to actin repolymerization in macrophages. |
| Cellular Location | Cytoplasm {ECO:0000250|UniProtKB:Q9JLC3}. Nucleus {ECO:0000250|UniProtKB:Q9JLC3}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q9JLC3} |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a selenoprotein, which contains aselenocysteine (Sec) residue at its active site. The selenocysteineis encoded by the UGA codon that normally signals translationtermination. The 3' UTR of selenoprotein genes have a commonstem-loop structure, the sec insertion sequence (SECIS), that isnecessary for the recognition of UGA as a Sec codon rather than asa stop signal. This protein belongs to the methionine sulfoxidereductase B (MsrB) family, and it is expressed in a variety ofadult and fetal tissues.
References
Kakiuchi, C., et al. Am. J. Med. Genet. B Neuropsychiatr. Genet. 147B (5), 557-564 (2008) :Achilli, C., et al. J. Leukoc. Biol. 83(1):181-189(2008)Kim, H.Y., et al. Mol. Biol. Cell 15(3):1055-1064(2004)Moskovitz, J., et al. Biochem. Biophys. Res. Commun. 290(1):62-65(2002)Daniels, R.J., et al. Hum. Mol. Genet. 10(4):339-352(2001)
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