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TSFM Antibody (C-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P43897 |
|---|---|
| Clone Names | 100603092 |
| Gene ID | 10102 |
|---|---|
| Other Names | Elongation factor Ts, mitochondrial {ECO:0000255|HAMAP-Rule:MF_03135}, EF-Ts {ECO:0000255|HAMAP-Rule:MF_03135}, EF-TsMt {ECO:0000255|HAMAP-Rule:MF_03135}, TSFM {ECO:0000255|HAMAP-Rule:MF_03135} |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | TSFM {ECO:0000255|HAMAP-Rule:MF_03135} |
|---|---|
| Function | Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome. |
| Cellular Location | Mitochondrion. |
| Tissue Location | Expressed in all tissues, with the highest levels of expression in skeletal muscle, liver and kidney |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a mitochondrial translation elongationfactor. The encoded protein is an enzyme that catalyzes theexchange of guanine nucleotides on the translation elongationfactor Tu during the elongation step of mitchondrial proteintranslation. Mutations in this gene are associated with combinedoxidative phosphorylation deficiency-3 syndrome. Alternate splicingresults in multiple transcript variants.
References
Wang, W., et al. Nucleic Acids Res. (2010) In press :Smeitink, J.A., et al. Am. J. Hum. Genet. 79(5):869-877(2006)Antonicka, H., et al. Hum. Mol. Genet. 15(11):1835-1846(2006)Vernon, J.L., et al. Cytogenet. Cell Genet. 89 (3-4), 145-146 (2000) :Xin, H., et al. J. Biol. Chem. 270(29):17243-17249(1995)
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