TSSC1 Antibody (C-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q53HC9 |
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Clone Names | 100603136 |
Gene ID | 7260 |
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Other Names | Protein TSSC1, Tumor-suppressing STF cDNA 1 protein, Tumor-suppressing subchromosomal transferable fragment candidate gene 1 protein, TSSC1 |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | EIPR1 (HGNC:12383) |
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Function | Acts as a component of endosomal retrieval machinery that is involved in protein transport from early endosomes to either recycling endosomes or the trans-Golgi network (PubMed:27440922). Mediates the recruitment of Golgi-associated retrograde protein (GARP) complex to the trans-Golgi network and controls early endosome-to-Golgi transport of internalized protein(PubMed:27440922). Promotes the recycling of internalized transferrin receptor (TFRC) to the plasma membrane through interaction with endosome-associated recycling protein (EARP) complex (PubMed:27440922). Controls proper insulin distribution and secretion, and retention of cargo in mature dense core vesicles (By similarity). Required for the stability of the endosome-associated retrograde protein (EARP) complex subunits and for proper localization and association of EARP with membranes (By similarity). |
Cellular Location | Golgi apparatus, trans-Golgi network |
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Background
This gene has been reported in PMID 9403053 as one ofseveral tumor-suppressing subtransferable fragments located in theimprinted gene domain of 11p15.5, an important tumor-suppressorgene region. Alterations in this region have been associated withthe Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma,adrenocortical carcinoma, and lung, ovarian, and breast cancer.Alignment of this gene to genomic sequence data suggests that thisgene resides on chromosome 2 rather than chromosome 11. [providedby RefSeq].
References
Ewing, R.M., et al. Mol. Syst. Biol. 3, 89 (2007) :Hillier, L.W., et al. Nature 434(7034):724-731(2005)Scelfo, R., et al. Cytogenet. Cell Genet. 83 (1-2), 52-53 (1998) :Hu, R.J., et al. Genomics 46(1):9-17(1997)
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