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FBXO11 Antibody (N-term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession Q86XK2
Clone Names 100603003
Peptide ID 100603003
Additional Information
Gene ID 80204
Other Names F-box only protein 11, Protein arginine N-methyltransferase 9, Vitiligo-associated protein 1, VIT-1, FBXO11, FBX11, PRMT9, VIT1
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name FBXO11
Synonyms FBX11, PRMT9, VIT1
Function Substrate recognition component of a SCF (SKP1-CUL1-F- box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as DTL/CDT2, BCL6 and PRDM1/BLIMP1. The SCF(FBXO11) complex mediates ubiquitination and degradation of BCL6, thereby playing a role in the germinal center B-cells terminal differentiation toward memory B-cells and plasma cells. The SCF(FBXO11) complex also mediates ubiquitination and degradation of DTL, an important step for the regulation of TGF- beta signaling, cell migration and the timing of the cell-cycle progression and exit. Binds to and neddylates phosphorylated p53/TP53, inhibiting its transcriptional activity. SCF(FBXO11) does not seem to direct ubiquitination of p53/TP53.
Cellular Location Nucleus. Chromosome.
Tissue Location Isoform 5 is expressed in keratinocytes, fibroblasts and melanocytes.
Research Areas
Citations (0)

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This gene encodes a member of the F-box protein familywhich is characterized by an approximately 40 amino acid motif, theF-box. The F-box proteins constitute one of the four subunits ofubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box),which function in phosphorylation-dependent ubiquitination. TheF-box proteins are divided into 3 classes: Fbws containing WD-40domains, Fbls containing leucine-rich repeats, and Fbxs containingeither different protein-protein interaction modules or norecognizable motifs. The protein encoded by this gene belongs tothe Fbxs class. It can function as an arginine methyltransferasethat symmetrically dimethylates arginine residues, and it acts asan adaptor protein to mediate the neddylation of p53, which leadsto the suppression of p53 function. This gene is known to bedown-regulated in melanocytes from patients with vitiligo, a skindisorder that results in depigmentation. Polymorphisms in this geneare associated with chronic otitis media with effusion andrecurrent otitis media (COME/ROM), a hearing loss disorder, and theknockout of the homologous mouse gene results in the deaf mousemutant Jeff (Jf), a single gene model of otitis media.Alternatively spliced transcript variants encoding distinctisoforms have been identified for this gene.


Guan, C., et al. Int. J. Mol. Med. 26(1):57-65(2010)Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Guan, C.P., et al. Zhonghua Yi Xue Za Zhi 90(16):1126-1130(2010)Abida, W.M., et al. J. Biol. Chem. 282(3):1797-1804(2007)Segade, F., et al. Arch. Otolaryngol. Head Neck Surg. 132(7):729-733(2006)

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$ 80.00
Cat# BP16914a
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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