|Other Names||Non-canonical poly(A) RNA polymerase PAPD7, DNA polymerase sigma, LAK-1, PAP-associated domain-containing protein 7, TRAMP-like complex polyadenylate polymerase, Terminal uridylyltransferase 5, TUTase 5, Topoisomerase-related function protein 4-1, TRF4-1, PAPD7, POLS, TRF4|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Catalytic subunit of a TRAMP-like complex which has a poly(A) RNA polymerase activity and is involved in a post- transcriptional quality control mechanism. Polyadenylation with short oligo(A) tails is required for the degradative activity of the exosome on several of its nuclear RNA substrates. Has no terminal uridylyltransferase activity, and does not play a role in replication-dependent histone mRNA degradation via uridylation.|
|Cellular Location||Cytoplasm. Nucleus, nucleoplasm. Note=Excluded from nucleolus, weak staining detected in the cytoplasm|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is a DNA polymerase thatis likely involved in DNA repair. In addition, the encoded proteinmay be required for sister chromatid adhesion. Alternativelyspliced transcript variants that encode different isoforms havebeen described.
Jarjanazi, H., et al. Hum. Mutat. 29(4):461-467(2008)Carson, D.R., et al. Proc. Natl. Acad. Sci. U.S.A. 98(15):8270-8275(2001)Wang, Z., et al. Science 289(5480):774-779(2000)Walowsky, C., et al. J. Biol. Chem. 274(11):7302-7308(1999)
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