|Other Names||Protein tyrosine phosphatase type IVA 1, PTP(CAAXI), Protein-tyrosine phosphatase 4a1, Protein-tyrosine phosphatase of regenerating liver 1, PRL-1, PTP4A1, PRL1, PTPCAAX1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. May play a role in the development and maintenance of differentiating epithelial tissues. Enhances cell proliferation, cell motility and invasive activity, and promotes cancer metastasis.|
|Cellular Location||Cell membrane. Early endosome. Endoplasmic reticulum. Cytoplasm. Cytoplasm, cytoskeleton, spindle. Note=And mitotic spindle|
|Tissue Location||Expressed in bone marrow, lymph nodes, T lymphocytes, spleen, thymus and tonsil. Overexpressed in tumor cell lines.|
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The protein encoded by this gene belongs to a small classof prenylated protein tyrosine phosphatases (PTPs), which containsa PTP domain and a characteristic C-terminal prenylation motif.PTPs are cell signaling molecules that play regulatory roles in avariety of cellular processes. This tyrosine phosphatase is anuclear protein, but may primarily associate with plasma membrane.The surface membrane association of this protein depends on itsC-terminal prenylation. Overexpression of this gene in mammaliancells conferred a transformed phenotype, which implicated its rolein the tumorigenesis. Studies in rat suggested that this gene maybe an immediate-early gene in mitogen-stimulated cells. [providedby RefSeq].
Johnatty, S.E., et al. PLoS Genet. 6 (7), E1001016 (2010) :Skinner, A.L., et al. Biochemistry 48(20):4262-4272(2009)Luo, Y., et al. Biochemistry 48(8):1838-1846(2009)Min, S.H., et al. Oncogene 28(4):545-554(2009)Liu, Y.Q., et al. Arch. Pathol. Lab. Med. 132(8):1307-1312(2008)
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