|Other Names||Tyrosine-protein phosphatase non-receptor type 18, Brain-derived phosphatase, PTPN18, BDP1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Differentially dephosphorylate autophosphorylated tyrosine kinases which are known to be overexpressed in tumor tissues.|
|Cellular Location||Nucleus. Cytoplasm|
|Tissue Location||Expressed in brain, colon and several tumor- derived cell lines.|
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The protein encoded by this gene is a member of theprotein tyrosine phosphatase (PTP) family. PTPs are known to besignaling molecules that regulate a variety of cellular processesincluding cell growth, differentiation, the mitotic cycle, andoncogenic transformation. This PTP contains a PEST motif, whichoften serves as a protein-protein interaction domain, and may berelated to protein intracellular half-live. This protein candifferentially dephosphorylate autophosphorylated tyrosine kinasesthat are overexpressed in tumor tissues, and it appears to regulateHER2, a member of the epidermal growth factor receptor family ofreceptor tyrosine kinases. Two transcript variants encodingdifferent isoforms have been found for this gene. [provided byRefSeq].
Oh, J.H., et al. Mamm. Genome 16(12):942-954(2005)Zhang, Y., et al. Mol. Cell Proteomics 4(9):1240-1250(2005)Tao, W.A., et al. Nat. Methods 2(8):591-598(2005)Blanchetot, C., et al. Methods 35(1):44-53(2005)Gandhi, T.K., et al. DNA Res. 12(2):79-89(2005)
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