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PTPN18 Antibody (C-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q99952 |
|---|---|
| Clone Names | 100617184 |
| Gene ID | 26469 |
|---|---|
| Other Names | Tyrosine-protein phosphatase non-receptor type 18, Brain-derived phosphatase, PTPN18, BDP1 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | PTPN18 |
|---|---|
| Synonyms | BDP1 |
| Function | Differentially dephosphorylate autophosphorylated tyrosine kinases which are known to be overexpressed in tumor tissues. |
| Cellular Location | Nucleus. Cytoplasm. |
| Tissue Location | Expressed in brain, colon and several tumor-derived cell lines. |
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Provided below are standard protocols that you may find useful for product applications.
Background
The protein encoded by this gene is a member of theprotein tyrosine phosphatase (PTP) family. PTPs are known to besignaling molecules that regulate a variety of cellular processesincluding cell growth, differentiation, the mitotic cycle, andoncogenic transformation. This PTP contains a PEST motif, whichoften serves as a protein-protein interaction domain, and may berelated to protein intracellular half-live. This protein candifferentially dephosphorylate autophosphorylated tyrosine kinasesthat are overexpressed in tumor tissues, and it appears to regulateHER2, a member of the epidermal growth factor receptor family ofreceptor tyrosine kinases. Two transcript variants encodingdifferent isoforms have been found for this gene. [provided byRefSeq].
References
Oh, J.H., et al. Mamm. Genome 16(12):942-954(2005)Zhang, Y., et al. Mol. Cell Proteomics 4(9):1240-1250(2005)Tao, W.A., et al. Nat. Methods 2(8):591-598(2005)Blanchetot, C., et al. Methods 35(1):44-53(2005)Gandhi, T.K., et al. DNA Res. 12(2):79-89(2005)
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