|Other Names||Taste receptor type 2 member 38, T2R38, PTC bitter taste receptor, Taste receptor type 2 member 61, T2R61, TAS2R38, PTC|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5 (By similarity).|
|Cellular Location||Membrane; Multi-pass membrane protein.|
|Tissue Location||Expressed in subsets of taste receptor cells of the tongue and exclusively in gustducin-positive cells|
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This gene encodes a seven-transmembrane G protein-coupledreceptor that controls the ability to taste glucosinolates, afamily of bitter-tasting compounds found in plants of the Brassicasp. Synthetic compounds phenylthiocarbamide (PTC) and6-n-propylthiouracil (PROP) have been identified as ligands forthis receptor and have been used to test the genetic diversity ofthis gene. Although several allelic forms of this gene have beenidentified worldwide, there are two predominant common forms(taster and non-taster) found outside of Africa. These allelesdiffer at three nucleotide positions resulting in amino acidchanges in the protein (A49P, A262V, and V296I) with the amino acidcombination PAV identifying the taster variant (and AVI identifyingthe non-taster variant).
Reed, D.R., et al. Hum. Mol. Genet. 19(21):4278-4285(2010)Wendell, S., et al. J. Dent. Res. 89(11):1198-1202(2010)Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Wooding, S., et al. Chem. Senses 35(8):685-692(2010)Mennella, J.A., et al. BMC Genet. 11, 60 (2010) :
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