|Other Names||Rho guanine nucleotide exchange factor 11, PDZ-RhoGEF, ARHGEF11, KIAA0380|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||May play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13). Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase and may act as GTPase-activating protein (GAP) for GNA12 and GNA13. Involved in neurotrophin-induced neurite outgrowth.|
|Cellular Location||Cytoplasm. Membrane. Note=Translocated to the membrane upon stimulation|
|Tissue Location||Ubiquitously expressed.|
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Rho GTPases play a fundamental role in numerous cellularprocesses that are initiated by extracellular stimuli that workthrough G protein coupled receptors. The encoded protein may form acomplex with G proteins and stimulate Rho-dependent signals. Asimilar protein in rat interacts with glutamate transporter EAAT4and modulates its glutamate transport activity. Expression of therat protein induces the reorganization of the actin cytoskeletonand its overexpression induces the formation of membrane rufflingand filopodia. Two alternative transcripts encoding differentisoforms have been described.
Akiyama, K., et al. J. Hum. Genet. (2010) In press :Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Ying, Z., et al. Arterioscler. Thromb. Vasc. Biol. 29(10):1657-1663(2009)Banerjee, J., et al. Biochemistry 48(33):8032-8043(2009)Zheng, M., et al. BMC Struct. Biol. 9, 36 (2009) :
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