|Other Names||MutS protein homolog 5, hMSH5, MSH5|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Involved in meiotic recombination. Facilitate crossovers between homologs during meiosis (By similarity).|
|Tissue Location||Ubiquitous, but highly expressed in testis, and thymus|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a member of the mutS family of proteinsthat are involved in DNA mismatch repair and meiotic recombination.This protein is similar to a Saccharomyces cerevisiae protein thatparticipates in segregation fidelity and crossing-over eventsduring meiosis. This protein plays a role in promoting ionizingradiation-induced apoptosis. This protein forms heterooligomerswith another member of this family, mutS homolog 4. Polymorphismsin this gene have been linked to various human diseases, includingIgA deficiency, common variable immunodeficiency, and prematureovarian failure. Alternative splicing results multiple transcriptvariants.
Ucisik-Akkaya, E., et al. Mol. Hum. Reprod. 16(10):770-777(2010)Pozo, N.D., et al. Hum. Immunol. 71(9):861-864(2010)Snowden, T., et al. J. Biol. Chem. 283(1):145-154(2008)Sekine, H., et al. Proc. Natl. Acad. Sci. U.S.A. 104(17):7193-7198(2007)Yi, W., et al. Biochem. Biophys. Res. Commun. 332(2):524-532(2005)
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