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MSH5 Antibody (Center) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | O43196 |
|---|---|
| Clone Names | 100623146 |
| Gene ID | 4439 |
|---|---|
| Other Names | MutS protein homolog 5, hMSH5, MSH5 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | MSH5 |
|---|---|
| Function | Involved in DNA mismatch repair and meiotic recombination processes. Facilitates crossovers between homologs during meiosis (By similarity). |
| Tissue Location | Widely expressed, with high levels in testis and ovary, including granulosa cells (PubMed:9740671, PubMed:28175301) Also expressed in fetal ovary and adrenal gland (PubMed:28175301) |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a member of the mutS family of proteinsthat are involved in DNA mismatch repair and meiotic recombination.This protein is similar to a Saccharomyces cerevisiae protein thatparticipates in segregation fidelity and crossing-over eventsduring meiosis. This protein plays a role in promoting ionizingradiation-induced apoptosis. This protein forms heterooligomerswith another member of this family, mutS homolog 4. Polymorphismsin this gene have been linked to various human diseases, includingIgA deficiency, common variable immunodeficiency, and prematureovarian failure. Alternative splicing results multiple transcriptvariants.
References
Ucisik-Akkaya, E., et al. Mol. Hum. Reprod. 16(10):770-777(2010)Pozo, N.D., et al. Hum. Immunol. 71(9):861-864(2010)Snowden, T., et al. J. Biol. Chem. 283(1):145-154(2008)Sekine, H., et al. Proc. Natl. Acad. Sci. U.S.A. 104(17):7193-7198(2007)Yi, W., et al. Biochem. Biophys. Res. Commun. 332(2):524-532(2005)
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