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DBNL Antibody (C-term) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession Q9UJU6
Clone Names 100623153
Peptide ID 100623153
Additional Information
Gene ID 28988
Other Names Drebrin-like protein, Cervical SH3P7, Cervical mucin-associated protein, Drebrin-F, HPK1-interacting protein of 55 kDa, HIP-55, SH3 domain-containing protein 7, DBNL, CMAP, SH3P7
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name DBNL
Synonyms CMAP, SH3P7
Function Adapter protein that binds F-actin and DNM1, and thereby plays a role in receptor-mediated endocytosis. Plays a role in the reorganization of the actin cytoskeleton, formation of cell projections, such as neurites, in neuron morphogenesis and synapse formation via its interaction with WASL and COBL. Does not bind G- actin and promote actin polymerization by itself. Required for the formation of organized podosome rosettes (By similarity). May act as a common effector of antigen receptor-signaling pathways in leukocytes. Acts as a key component of the immunological synapse that regulates T-cell activation by bridging TCRs and the actin cytoskeleton to gene activation and endocytic processes.
Cellular Location Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q62418}. Cell projection, lamellipodium {ECO:0000250|UniProtKB:Q62418}. Cell projection, ruffle {ECO:0000250|UniProtKB:Q62418}. Cytoplasm, cell cortex {ECO:0000250|UniProtKB:Q62418}. Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q62418}. Cell junction, synapse {ECO:0000250|UniProtKB:Q62418}. Cell projection {ECO:0000250|UniProtKB:Q62418}. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic vesicle, clathrin- coated vesicle membrane {ECO:0000250|UniProtKB:Q62418}; Peripheral membrane protein; Cytoplasmic side. Golgi apparatus membrane {ECO:0000250|UniProtKB:Q62418}; Peripheral membrane protein; Cytoplasmic side. Cell projection, podosome {ECO:0000250|UniProtKB:Q62418}. Early endosome. Note=Detected in neuron cell body and cell projections, such as neurites. Colocalizes with cytosolic dynamin in hippocampus neurons (By similarity). Cortical actin cytoskeleton. Associates with lamellipodial actin and membrane ruffles. Colocalizes with actin and cortactin at podosome dots and podosome rosettes (By similarity). {ECO:0000250|UniProtKB:Q62418}
Research Areas
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Background

Actin-binding adapter protein. May act as a common effector of antigen receptor-signaling pathways in leukocytes. Its association with dynamin suggests that it may also connect the actin cytoskeleton to endocytic function. Acts as a key component of the immunological synapse that regulates T-cell activation by bridging TCRs and the actin cytoskeleton to gene activation and endocytic processes. Binds to F-actin but is not involved in actin polymerization, capping or bundling. Does not bind G-actin.

References

Venkatesan, K., et al. Nat. Methods 6(1):83-90(2009)Haeckel, A., et al. J. Neurosci. 28(40):10031-10044(2008)Le Bras, S., et al. FEBS Lett. 581(5):967-974(2007)Lamesch, P., et al. Genomics 89(3):307-315(2007)Ewing, R.M., et al. Mol. Syst. Biol. 3, 89 (2007) :

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$ 80.00
Cat# BP16932b
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