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PI4K2A Antibody (C-term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession Q9BTU6
Clone Names 100617110
Peptide ID 100617110
Additional Information
Gene ID 55361
Other Names Phosphatidylinositol 4-kinase type 2-alpha, Phosphatidylinositol 4-kinase type II-alpha, PI4K2A
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name PI4K2A
Function Membrane-bound phosphatidylinositol-4 kinase (PI4- kinase) that catalyzes the phosphorylation of phosphatidylinositol (PI) to phosphatidylinositol 4-phosphate (PI4P), a lipid that plays important roles in endocytosis, Golgi function, protein sorting and membrane trafficking and is required for prolonged survival of neurons. Besides, phosphorylation of phosphatidylinositol (PI) to phosphatidylinositol 4-phosphate (PI4P) is the first committed step in the generation of phosphatidylinositol 4,5-bisphosphate (PIP2), a precursor of the second messenger inositol 1,4,5-trisphosphate (InsP3).
Cellular Location Golgi apparatus, trans-Golgi network membrane; Lipid-anchor. Membrane raft. Cell projection, dendrite {ECO:0000250|UniProtKB:Q2TBE6}. Cell junction, synapse, presynaptic cell membrane {ECO:0000250|UniProtKB:Q2TBE6}. Cell junction, synapse, synaptosome {ECO:0000250|UniProtKB:Q2TBE6} Mitochondrion {ECO:0000250|UniProtKB:Q2TBE6}. Endosome Cytoplasmic vesicle. Membrane; Lipid-anchor. Cell membrane Note=Localized in neuronal cell body. Transported from neuronal cell body to neuron projections in a BLOC-1- and AP-3-complexes- dependent manner. Enriched in neurite tips and neuron projections in a BLOC-1- and AP-3-complexes-dependent manner (By similarity) Found in subdomains of the plasma membrane termed non-caveolar membrane rafts. {ECO:0000250|UniProtKB:Q2TBE6, ECO:0000250|UniProtKB:Q99M64}
Tissue Location Widely expressed. Highest expression is observed in kidney, brain, heart, skeletal muscle, and placenta and lowest expression is observed in colon, thymus, and small intestine.
Research Areas
Citations (0)

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Phosphatidylinositolpolyphosphates (PtdInsPs) arecentrally involved in many biologic processes, ranging from cellgrowth and organization of the actin cytoskeleton to endo- andexocytosis. PI4KII phosphorylates PtdIns at the D-4 position, anessential step in the biosynthesis of PtdInsPs (Barylko et al.,2001 [PubMed 11244087]).


Li, J., et al. Oncogene 29(17):2550-2559(2010)Qin, Y., et al. J. Biol. Chem. 284(34):22544-22548(2009)Salazar, G., et al. J. Biol. Chem. 284(3):1790-1802(2009)Craige, B., et al. Mol. Biol. Cell 19(4):1415-1426(2008)Olsen, J.V., et al. Cell 127(3):635-648(2006)

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$ 80.00
Cat# BP16933b
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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