MGAT1 Antibody (Center) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | P26572 |
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Clone Names | 100617116 |
Gene ID | 4245 |
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Other Names | Alpha-1, 3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase, N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase I, GNT-I, GlcNAc-T I, MGAT1, GGNT1, GLCT1, GLYT1, MGAT |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | MGAT1 |
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Synonyms | GGNT1, GLCT1, GLYT1, MGAT |
Function | Initiates complex N-linked carbohydrate formation. Essential for the conversion of high-mannose to hybrid and complex N-glycans. |
Cellular Location | Golgi apparatus membrane; Single-pass type II membrane protein. Cytoplasm, perinuclear region. Note=Co-localizes with BRI3 isoform 1 at the perinuclear region. |
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Provided below are standard protocols that you may find useful for product applications.
Background
There are believed to be over 100 differentglycosyltransferases involved in the synthesis of protein-bound andlipid-bound oligosaccharides.UDP-N-acetylglucosamine:alpha-3-D-mannosidebeta-1,2-N-acetylglucosaminyltransferase I is a medial-Golgi enzymeessential for the synthesis of hybrid and complex N-glycans. Theprotein, encoded by a single exon, shows typical features of a typeII transmembrane protein. The protein is believed to be essentialfor normal embryogenesis. Several variants encoding the sameprotein have been found for this gene.
References
Henquet, M., et al. Transgenic Res. 19(4):535-547(2010)Johansson, A., et al. Obesity (Silver Spring) 18(4):803-808(2010)Bousman, C.A., et al. Am. J. Med. Genet. B Neuropsychiatr. Genet. 150B (8), 1025-1049 (2009) :Lowe, J.K., et al. PLoS Genet. 5 (2), E1000365 (2009) :Saribas, A.S., et al. Biochem. Biophys. Res. Commun. 362(2):381-386(2007)
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