|Other Names||Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2, Centaurin-delta-1, Cnt-d1, Protein PARX, ARAP2, CENTD1, KIAA0580|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Phosphatidylinositol 3,4,5-trisphosphate-dependent GTPase-activating protein that modulates actin cytoskeleton remodeling by regulating ARF and RHO family members. Is activated by phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3) binding. Can be activated by phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4,5)P2) binding, albeit with lower efficiency (By similarity).|
|Tissue Location||Detected in brain, thymus, lymph node, thyroid, spinal cord, trachea, heart, skeletal muscle, spleen, kidney, liver, placenta, lung and peripheral blood leukocytes|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene contains ARF-GAP,RHO-GAP, ankyrin repeat, RAS-associating, and pleckstrin homologydomains. The protein is a phosphatidylinositol(3,4,5)-trisphosphate-dependent Arf6 GAP that binds RhoA-GTP, butit lacks the predicted catalytic arginine in the RHO-GAP domain anddoes not have RHO-GAP activity. The protein associates with focaladhesions and functions downstream of RhoA to regulate focaladhesion dynamics.
Gavicherla, B., et al. Infect. Immun. 78(11):4532-4541(2010)Liu, C., et al. Mol. Med. 14 (9-10), 575-581 (2008) :Yoon, H.Y., et al. J. Cell. Sci. 119 (PT 22), 4650-4666 (2006) :Olsen, J.V., et al. Cell 127(3):635-648(2006)Olsen, J.V., et al. Cell 127(3):635-648(2006)
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