NCDN Antibody (N-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q9UBB6 |
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Clone Names | 110717120 |
Gene ID | 23154 |
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Other Names | Neurochondrin, NCDN, KIAA0607 |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | NCDN (HGNC:17597) |
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Synonyms | KIAA0607 |
Function | Probably involved in signal transduction in the nervous system, via increasing cell surface localization of GRM5/mGluR5 and positively regulating its signaling (PubMed:33711248). Required for the spatial learning process. Acts as a negative regulator of Ca(2+)- calmodulin-dependent protein kinase 2 (CaMK2) phosphorylation. May play a role in modulating melanin-concentrating hormone-mediated functions via its interaction with MCHR1 that interferes with G protein-coupled signal transduction. May be involved in bone metabolism. May also be involved in neurite outgrowth (Probable). |
Cellular Location | Cytoplasm, cytosol. Endosome membrane {ECO:0000250|UniProtKB:O35095}; Lipid-anchor. Cell projection, dendrite {ECO:0000250|UniProtKB:O35095}. Postsynapse {ECO:0000250|UniProtKB:O35095}. Note=Localizes to somatic regions of neurons. Localization to endosome membrane requires palmitoylation {ECO:0000250|UniProtKB:O35095} |
Tissue Location | Abundantly expressed in whole adult brain and in all individual brain regions examined, including spinal cord. Weakly expressed in ovary, testis, fetal brain and small intestine |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a leucine-rich cytoplasmic protein,which is highly similar to a mouse protein that negativelyregulates Ca/calmodulin-dependent protein kinase II phosphorylationand may be essential for spatial learning processes. Severalalternatively spliced transcript variants of this gene have beendescribed.
References
Dateki, M., et al. J. Biol. Chem. 280(21):20503-20508(2005)Mochizuki, R., et al. Biochem. Biophys. Res. Commun. 310(4):1219-1226(2003)Tchernev, V.T., et al. Mol. Med. 8(1):56-64(2002)Ohoka, Y., et al. Biochem. Biophys. Res. Commun. 280(1):237-243(2001)Mochizuki, R., et al. Biochim. Biophys. Acta 1490(3):367-368(2000)
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