|Other Names||Neurochondrin, NCDN, KIAA0607|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Probably involved in signal transduction, in the nervous system, via increasing cell surface localization of GRM5 and positively regulating its signaling (By similarity). Required for the spatial learning process. Acts as a negative regulator of Ca(2+)-calmodulin-dependent protein kinase 2 (CaMK2) phosphorylation. May play a role in modulating melanin- concentrating hormone-mediated functions via its interaction with MCHR1 that interferes with G protein-coupled signal transduction. May be involved in bone metabolism. May also be involved in neurite outgrowth.|
|Cellular Location||Cytoplasm, cytosol. Cell projection, dendrite. Note=Localizes to somatic regions of neurons|
|Tissue Location||Abundantly expressed in whole adult brain and in all individual brain regions examined, including spinal cord Weakly expressed in ovary, testis, fetal brain and small intestine.|
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This gene encodes a leucine-rich cytoplasmic protein,which is highly similar to a mouse protein that negativelyregulates Ca/calmodulin-dependent protein kinase II phosphorylationand may be essential for spatial learning processes. Severalalternatively spliced transcript variants of this gene have beendescribed.
Dateki, M., et al. J. Biol. Chem. 280(21):20503-20508(2005)Mochizuki, R., et al. Biochem. Biophys. Res. Commun. 310(4):1219-1226(2003)Tchernev, V.T., et al. Mol. Med. 8(1):56-64(2002)Ohoka, Y., et al. Biochem. Biophys. Res. Commun. 280(1):237-243(2001)Mochizuki, R., et al. Biochim. Biophys. Acta 1490(3):367-368(2000)
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