|Other Names||Inactive peptidyl-prolyl cis-trans isomerase FKBP6, Inactive PPIase FKBP6, 36 kDa FK506-binding protein, 36 kDa FKBP, FKBP-36, FK506-binding protein 6, FKBP-6, Immunophilin FKBP36, FKBP6, FKBP36|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Co-chaperone required during spermatogenesis to repress transposable elements and prevent their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Acts as a co-chaperone via its interaction with HSP90 and is required for the piRNA amplification process, the secondary piRNA biogenesis. May be required together with HSP90 in removal of 16 nucleotide ping-pong by-products from Piwi complexes, possibly facilitating turnover of Piwi complexes (By similarity).|
|Cellular Location||Cytoplasm, cytosol. Nucleus. Chromosome. Note=Does not localize to pi-bodies. Localizes to meiotic chromosome cores and regions of homologous chromosome synapsis (By similarity).|
|Tissue Location||Detected in all tissues examined, with higher expression in testis, heart, skeletal muscle, liver, and kidney|
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The protein encoded by this gene is a member of theimmunophilin protein family, which play a role in immunoregulationand basic cellular processes involving protein folding andtrafficking. The protein may have cis-trans prolyl isomeraseactivity, and binds to clathrin heavy chain and heat shock protein72. This gene is found to be deleted in Williams syndrome, and theorthologous gene in mouse is essential for fertility and homologouspairing in male meiosis.
Aston, K.I., et al. Hum. Reprod. 25(6):1383-1397(2010)Jarczowski, F., et al. J. Biol. Chem. 284(2):766-773(2009)Jarczowski, F., et al. Biochemistry 47(26):6946-6952(2008)Zhang, W., et al. Reproduction 133(2):511-516(2007)Miyamato, T., et al. Cell. Mol. Biol. Lett. 11(4):557-569(2006)
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