|Other Names||39S ribosomal protein L39, mitochondrial, L39mt, MRP-L39, 39S ribosomal protein L5, mitochondrial, L5mt, MRP-L5, MRPL39, C21orf92, MRPL5, RPML5|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Synonyms||C21orf92, MRPL5, RPML5|
|Tissue Location||Isoform 1 is ubiquitously expressed. Isoform 2 is heart-specific|
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Mammalian mitochondrial ribosomal proteins are encoded bynuclear genes and help in protein synthesis within themitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of asmall 28S subunit and a large 39S subunit. They have an estimated75% protein to rRNA composition compared to prokaryotic ribosomes,where this ratio is reversed. Another difference between mammalianmitoribosomes and prokaryotic ribosomes is that the latter containa 5S rRNA. Among different species, the proteins comprising themitoribosome differ greatly in sequence, and sometimes inbiochemical properties, which prevents easy recognition by sequencehomology. This gene encodes a 39S subunit protein. Two transcriptvariants encoding distinct isoforms have been described. Apseudogene corresponding to this gene is found on chromosome 5q.
Need, A.C., et al. Hum. Mol. Genet. 18(23):4650-4661(2009)Zhang, Z., et al. Genomics 81(5):468-480(2003)O'Brien, T.W. Gene 286(1):73-79(2002)Kenmochi, N., et al. Genomics 77 (1-2), 65-70 (2001) :Spirina, O., et al. Gene 261(2):229-234(2000)
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