|Other Names||Ras association domain-containing protein 7, HRAS1-related cluster protein 1, RASSF7, C11orf13, HRC1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Negatively regulates stress-induced JNK activation and apoptosis by promoting MAP2K7 phosphorylation and inhibiting its ability to activate JNK. Following prolonged stress, anti- apoptotic effect stops because of degradation of RASSF7 protein via the ubiquitin-proteasome pathway. Required for the activation of AURKB and chromosomal congression during mitosis where it stimulates microtubule polymerization.|
|Cellular Location||Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Note=Colocalizes with gamma-tubulin|
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Provided below are standard protocols that you may find useful for product applications.
RASSF7 contains 1 Ras-associating domain. It is a centrosome-associated protein required to form a spindle and complete mitosis in the neural tube. There are two isoforms.
Recino, A., et al. Biochem. J. 430(2):207-213(2010)Lescai, F., et al. Eur. J. Hum. Genet. 17(11):1515-1519(2009)Sherwood, V., et al. Mol. Biol. Cell 19(4):1772-1782(2008)Tsang, H.T., et al. Genomics 88(3):333-346(2006)Iarmolinskii, D.G., et al. Tsitol. Genet. 38(1):9-14(2004)
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