RASSF7 Antibody (C-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q02833 |
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Clone Names | 100405247 |
Gene ID | 8045 |
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Other Names | Ras association domain-containing protein 7, HRAS1-related cluster protein 1, RASSF7, C11orf13, HRC1 |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | RASSF7 |
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Synonyms | C11orf13, HRC1 |
Function | Negatively regulates stress-induced JNK activation and apoptosis by promoting MAP2K7 phosphorylation and inhibiting its ability to activate JNK. Following prolonged stress, anti-apoptotic effect stops because of degradation of RASSF7 protein via the ubiquitin-proteasome pathway. Required for the activation of AURKB and chromosomal congression during mitosis where it stimulates microtubule polymerization. |
Cellular Location | Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Colocalizes with gamma-tubulin |
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Provided below are standard protocols that you may find useful for product applications.
Background
RASSF7 contains 1 Ras-associating domain. It is a centrosome-associated protein required to form a spindle and complete mitosis in the neural tube. There are two isoforms.
References
Recino, A., et al. Biochem. J. 430(2):207-213(2010)Lescai, F., et al. Eur. J. Hum. Genet. 17(11):1515-1519(2009)Sherwood, V., et al. Mol. Biol. Cell 19(4):1772-1782(2008)Tsang, H.T., et al. Genomics 88(3):333-346(2006)Iarmolinskii, D.G., et al. Tsitol. Genet. 38(1):9-14(2004)
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