WNT9B Antibody (Center) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | O14905 |
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Clone Names | 100406006 |
Gene ID | 7484 |
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Other Names | Protein Wnt-9b, Protein Wnt-14b, Protein Wnt-15, WNT9B, WNT14B, WNT15 |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | WNT9B |
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Synonyms | WNT14B {ECO:0000303|PubMed:11604992}, WN |
Function | Ligand for members of the frizzled family of seven transmembrane receptors (Probable). Functions in the canonical Wnt/beta-catenin signaling pathway. Required for normal embryonic kidney development, and for normal development of the urogenital tract, including uterus and part of the oviduct and the upper vagina in females, and epididymis and vas deferens in males. Activates a signaling cascade in the metanephric mesenchyme that induces tubulogenesis. Acts upstream of WNT4 in the signaling pathways that mediate development of kidney tubules and the Muellerian ducts. Plays a role in cranofacial development and is required for normal fusion of the palate during embryonic development (By similarity). |
Cellular Location | Secreted, extracellular space, extracellular matrix. Secreted |
Tissue Location | Moderately expressed in fetal kidney and adult kidney. Also found in brain |
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Provided below are standard protocols that you may find useful for product applications.
Background
The WNT gene family consists of structurally related genesthat encode secreted signaling proteins. These proteins have beenimplicated in oncogenesis and in several developmental processes,including regulation of cell fate and patterning duringembryogenesis. This gene is a member of the WNT gene family. Studyof its expression in the teratocarcinoma cell line NT2 suggeststhat it may be implicated in the early process of neuronaldifferentiation of NT2 cells induced by retinoic acid. This gene isclustered with WNT3, another family member, in the chromosome 17q21region.
References
Nikopensius, T., et al. Birth Defects Res. Part A Clin. Mol. Teratol. 88(9):748-756(2010)Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Jugessur, A., et al. PLoS ONE 5 (7), E11493 (2010) :Ravel, C., et al. Fertil. Steril. 91 (4 SUPPL), 1604-1607 (2009) :Chiquet, B.T., et al. Hum. Mol. Genet. 17(14):2212-2218(2008)
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