|Other Names||Protein Wnt-9b, Protein Wnt-14b, Protein Wnt-15, WNT9B, WNT14B, WNT15|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters (By similarity).|
|Cellular Location||Secreted, extracellular space, extracellular matrix|
|Tissue Location||Moderately expressed in fetal kidney and adult kidney. Also found in brain|
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The WNT gene family consists of structurally related genesthat encode secreted signaling proteins. These proteins have beenimplicated in oncogenesis and in several developmental processes,including regulation of cell fate and patterning duringembryogenesis. This gene is a member of the WNT gene family. Studyof its expression in the teratocarcinoma cell line NT2 suggeststhat it may be implicated in the early process of neuronaldifferentiation of NT2 cells induced by retinoic acid. This gene isclustered with WNT3, another family member, in the chromosome 17q21region.
Nikopensius, T., et al. Birth Defects Res. Part A Clin. Mol. Teratol. 88(9):748-756(2010)Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Jugessur, A., et al. PLoS ONE 5 (7), E11493 (2010) :Ravel, C., et al. Fertil. Steril. 91 (4 SUPPL), 1604-1607 (2009) :Chiquet, B.T., et al. Hum. Mol. Genet. 17(14):2212-2218(2008)
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