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>   home   >   Products   >   Peptides   >   Blocking Peptides   >   ULBP3 Antibody (C-term) Blocking Peptide   

ULBP3 Antibody (C-term) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession Q9BZM4
Clone Names 100406139
Peptide ID 100406139
Additional Information
Gene ID 79465
Other Names NKG2D ligand 3, N2DL-3, NKG2DL3, ALCAN-gamma, Retinoic acid early transcript 1N, ULBP3, N2DL3, RAET1N
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name ULBP3
Synonyms N2DL3, RAET1N
Function Ligand for the KLRK1/NKG2D receptor, together with at least ULBP1 and ULBP2. ULBPs activate multiple signaling pathways in primary NK cells, resulting in the production of cytokines and chemokines. Binding of ULBPs ligands to KLRK1/NKG2D induces calcium mobilization and activation of the JAK2, STAT5, ERK and PI3K kinase/Akt signal transduction pathway. Has lower affinity for KLRK1/NKG2D compared to ULBP1 and ULBP2 and induces weaker signaling responses than does ULBP2 or ULBP1.
Cellular Location Cell membrane; Lipid-anchor, GPI-anchor.
Research Areas
Citations (0)

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Background

Ligand for the NKG2D receptor, together with at least ULBP1 and ULBP2. ULBPs activate multiple signaling pathways in primary NK cells, resulting in the production of cytokines and chemokines. Binding of ULBPs ligands to NKG2D induces calcium mobilization and activation of the JAK2, STAT5, ERK and PI3K kinase/Akt signal transduction pathway. Has lower affinity for NKG2D compared to ULBP1 and ULBP2 and induces weaker signaling responses than does ULBP2 or ULBP1.

References

Bennett, N.J., et al. J. Immunol. 185(2):1093-1102(2010)Petukhova, L., et al. Nature 466(7302):113-117(2010)Antoun, A., et al. Hum. Immunol. 71(6):610-620(2010)Davila, S., et al. Genes Immun. 11(3):232-238(2010)Ward, J., et al. PLoS Pathog. 5 (10), E1000613 (2009) :

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$ 80.00
Cat# BP16963b
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