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ULBP3 Antibody (C-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q9BZM4 |
|---|---|
| Clone Names | 100406139 |
| Gene ID | 79465 |
|---|---|
| Other Names | NKG2D ligand 3, N2DL-3, NKG2DL3, ALCAN-gamma, Retinoic acid early transcript 1N, ULBP3, N2DL3, RAET1N |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | ULBP3 |
|---|---|
| Synonyms | N2DL3, RAET1N |
| Function | Binds and activates the KLRK1/NKG2D receptor, mediating natural killer cell cytotoxicity. |
| Cellular Location | Cell membrane {ECO:0000250|UniProtKB:Q9BZM6}; Lipid-anchor, GPI-anchor {ECO:0000250|UniProtKB:Q9BZM6} |
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Provided below are standard protocols that you may find useful for product applications.
Background
Ligand for the NKG2D receptor, together with at least ULBP1 and ULBP2. ULBPs activate multiple signaling pathways in primary NK cells, resulting in the production of cytokines and chemokines. Binding of ULBPs ligands to NKG2D induces calcium mobilization and activation of the JAK2, STAT5, ERK and PI3K kinase/Akt signal transduction pathway. Has lower affinity for NKG2D compared to ULBP1 and ULBP2 and induces weaker signaling responses than does ULBP2 or ULBP1.
References
Bennett, N.J., et al. J. Immunol. 185(2):1093-1102(2010)Petukhova, L., et al. Nature 466(7302):113-117(2010)Antoun, A., et al. Hum. Immunol. 71(6):610-620(2010)Davila, S., et al. Genes Immun. 11(3):232-238(2010)Ward, J., et al. PLoS Pathog. 5 (10), E1000613 (2009) :
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