GUCY2F Antibody (C-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | P51841 |
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Clone Names | 100406150 |
Gene ID | 2986 |
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Other Names | Retinal guanylyl cyclase 2, RETGC-2, Guanylate cyclase 2F, retinal, Guanylate cyclase F, GC-F, Rod outer segment membrane guanylate cyclase 2, ROS-GC2, GUCY2F, GUC2F, RETGC2 |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | GUCY2F |
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Synonyms | GUC2F, RETGC2 |
Function | Responsible for the synthesis of cyclic GMP (cGMP) in rods and cones of photoreceptors (PubMed:7777544). Plays an essential role in phototransduction, by mediating cGMP replenishment (By similarity). May also participate in the trafficking of membrane-asociated proteins to the photoreceptor outer segment membrane (By similarity). |
Cellular Location | Photoreceptor outer segment membrane {ECO:0000250|UniProtKB:O02740}; Single-pass type I membrane protein |
Tissue Location | Retina. Localized exclusively in the outer nuclear layer and inner segments of the rod and cone photoreceptor cells |
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Provided below are standard protocols that you may find useful for product applications.
Background
The protein encoded by this gene is a guanylyl cyclasefound predominantly in photoreceptors in the retina. The encodedprotein is thought to be involved in resynthesis of cGMP afterlight activation of the visual signal transduction cascade,allowing a return to the dark state. This protein is a single-passtype I membrane protein. Defects in this gene may be a cause ofX-linked retinitis pigmentosa.
References
Blackford, A., et al. Cancer Res. 69(8):3681-3688(2009)Helten, A., et al. J. Neurochem. 103(4):1439-1446(2007)Wood, L.D., et al. Hum. Mutat. 27(10):1060-1061(2006)Ross, M.T., et al. Nature 434(7031):325-337(2005)Laura, R.P., et al. Biochemistry 37(32):11264-11271(1998)
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