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GUCY2F Antibody (C-term) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession P51841
Clone Names 100406150
Additional Information
Gene ID 2986
Other Names Retinal guanylyl cyclase 2, RETGC-2, Guanylate cyclase 2F, retinal, Guanylate cyclase F, GC-F, Rod outer segment membrane guanylate cyclase 2, ROS-GC2, GUCY2F, GUC2F, RETGC2
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name GUCY2F
Synonyms GUC2F, RETGC2
Function Responsible for the synthesis of cyclic GMP (cGMP) in rods and cones of photoreceptors (PubMed:7777544). Plays an essential role in phototransduction, by mediating cGMP replenishment (By similarity). May also participate in the trafficking of membrane-asociated proteins to the photoreceptor outer segment membrane (By similarity).
Cellular Location Photoreceptor outer segment membrane {ECO:0000250|UniProtKB:O02740}; Single-pass type I membrane protein
Tissue Location Retina. Localized exclusively in the outer nuclear layer and inner segments of the rod and cone photoreceptor cells
Research Areas
Citations (0)
citation

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Background

The protein encoded by this gene is a guanylyl cyclasefound predominantly in photoreceptors in the retina. The encodedprotein is thought to be involved in resynthesis of cGMP afterlight activation of the visual signal transduction cascade,allowing a return to the dark state. This protein is a single-passtype I membrane protein. Defects in this gene may be a cause ofX-linked retinitis pigmentosa.

References

Blackford, A., et al. Cancer Res. 69(8):3681-3688(2009)Helten, A., et al. J. Neurochem. 103(4):1439-1446(2007)Wood, L.D., et al. Hum. Mutat. 27(10):1060-1061(2006)Ross, M.T., et al. Nature 434(7031):325-337(2005)Laura, R.P., et al. Biochemistry 37(32):11264-11271(1998)

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$ 277.78
Cat# BP16965b
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