|Other Names||Retinal guanylyl cyclase 2, RETGC-2, Guanylate cyclase 2F, retinal, Guanylate cyclase F, GC-F, Rod outer segment membrane guanylate cyclase 2, ROS-GC2, GUCY2F, GUC2F, RETGC2|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Probably plays a specific functional role in the rods and/or cones of photoreceptors. It may be the enzyme involved in the resynthesis of cGMP required for recovery of the dark state after phototransduction.|
|Cellular Location||Membrane; Single-pass type I membrane protein|
|Tissue Location||Retina. Localized exclusively in the outer nuclear layer and inner segments of the rod and cone photoreceptor cells|
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The protein encoded by this gene is a guanylyl cyclasefound predominantly in photoreceptors in the retina. The encodedprotein is thought to be involved in resynthesis of cGMP afterlight activation of the visual signal transduction cascade,allowing a return to the dark state. This protein is a single-passtype I membrane protein. Defects in this gene may be a cause ofX-linked retinitis pigmentosa.
Blackford, A., et al. Cancer Res. 69(8):3681-3688(2009)Helten, A., et al. J. Neurochem. 103(4):1439-1446(2007)Wood, L.D., et al. Hum. Mutat. 27(10):1060-1061(2006)Ross, M.T., et al. Nature 434(7031):325-337(2005)Laura, R.P., et al. Biochemistry 37(32):11264-11271(1998)
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