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SLC9A4 Antibody (Center) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession Q6AI14
Clone Names 100416257
Peptide ID 100416257
Additional Information
Gene ID 389015
Other Names Sodium/hydrogen exchanger 4, Na(+)/H(+) exchanger 4, NHE-4, Solute carrier family 9 member 4, SLC9A4, NHE4
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name SLC9A4
Synonyms NHE4
Function Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Plays an important role in signal transduction. May play a specialized role in the kidney in rectifying cell volume in response to extreme fluctuations of hyperosmolar-stimulated cell shrinkage. Is relatively amiloride and ethylisopropylamiloride (EIPA) insensitive. Can be activated under conditions of hyperosmolar-induced cell shrinkage in a sustained intracellular acidification-dependence manner. Activated by 4,4'-diisothiocyanostilbene-2,2'-disulfonic acid (DIDS) in a sustained intracellular acidification-dependence manner. Affects potassium/proton exchange as well as sodium/proton and lithium/proton exchange. In basolateral cell membrane, participates in homeostatic control of intracellular pH, and may play a role in proton extrusion in order to achieve transepithelial HCO3(-) secretion. In apical cell membrane may be involved in mediating sodium absorption. Requires for normal levels of gastric acid secretion, secretory membrane development, parietal cell maturation and/or differentiation and at least secondarily for chief cell differentiation (By similarity).
Cellular Location Apical cell membrane; Multi- pass membrane protein. Basolateral cell membrane; Multi-pass membrane protein Cytoplasmic granule membrane; Multi-pass membrane protein. Note=Found in zymogen granule membranes
Research Areas
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Background

Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Plays an important role in signal transduction. May play a specialized role in the kidney in rectifying cell volume in response to extreme fluctuations of hyperosmolar-stimulated cell shrinkage. Is relatively amiloride and ethylisopropylamiloride (EIPA) insensitive. Can be activated under conditions of hyperosmolar-induced cell shrinkage in a sustained intracellular acidification-dependence manner. Activated by 4,4'-diisothiocyanostilbene-2,2'-disulfonic acid (DIDS) in a sustained intracellular acidification-dependence manner. Affects potassium/proton exchange as well as sodium/proton and lithium/proton exchange. In basolateral cell membrane, participates in homeostatic control of intracellular pH, and may play a role in proton extrusion in order to achieve transepithelial HCO3(-) secretion. In apical cell membrane may be involved in mediating sodium absorption. Requires for normal levels of gastric acid secretion, secretory membrane development, parietal cell maturation and/or differentiation and at least secondarily for chief cell differentiation (By similarity).

References

Dubois, P.C., et al. Nat. Genet. 42(4):295-302(2010)Hunt, K.A., et al. Nat. Genet. 40(4):395-402(2008)Beltran, A.R., et al. Pflugers Arch. 455(5):799-810(2008)Inoue, H., et al. Biol. Pharm. Bull. 26(2):148-155(2003)Szpirer, C., et al. Mamm. Genome 5(3):153-159(1994)

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$ 80.00
Cat# BP16972c
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