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MS4A1 Antibody (C-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P11836 |
|---|---|
| Clone Names | 100427006 |
| Gene ID | 931 |
|---|---|
| Other Names | B-lymphocyte antigen CD20, B-lymphocyte surface antigen B1, Bp35, Leukocyte surface antigen Leu-16, Membrane-spanning 4-domains subfamily A member 1, CD20, MS4A1, CD20 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | MS4A1 |
|---|---|
| Synonyms | CD20 |
| Function | B-lymphocyte-specific membrane protein that plays a role in the regulation of cellular calcium influx necessary for the development, differentiation, and activation of B-lymphocytes (PubMed:3925015, PubMed:7684739, PubMed:12920111). Functions as a store-operated calcium (SOC) channel component promoting calcium influx after activation by the B-cell receptor/BCR (PubMed:7684739, PubMed:12920111, PubMed:18474602). |
| Cellular Location | Cell membrane; Multi-pass membrane protein. Cell membrane; Lipid-anchor. Note=Constitutively associated with membrane rafts. |
| Tissue Location | Expressed on B-cells. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a member of the membrane-spanning 4Agene family. Members of this nascent protein family arecharacterized by common structural features and similar intron/exonsplice boundaries and display unique expression patterns amonghematopoietic cells and nonlymphoid tissues. This gene encodes aB-lymphocyte surface molecule which plays a role in the developmentand differentiation of B-cells into plasma cells. This familymember is localized to 11q12, among a cluster of family members.Alternative splicing of this gene results in two transcriptvariants which encode the same protein.
References
Weber, M.S., et al. Ann. Neurol. 68(3):369-383(2010)Wu, D., et al. Am. J. Clin. Pathol. 134(2):258-265(2010)de Haij, S., et al. Cancer Res. 70(8):3209-3217(2010)Beers, S.A., et al. Semin. Hematol. 47(2):107-114(2010)Davila, S., et al. Genes Immun. 11(3):232-238(2010)
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