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KRT6A Antibody (N-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P02538 |
|---|---|
| Clone Names | 100427176 |
| Gene ID | 3853 |
|---|---|
| Other Names | Keratin, type II cytoskeletal 6A, Cytokeratin-6A, CK-6A, Cytokeratin-6D, CK-6D, Keratin-6A, K6A, Type-II keratin Kb6, Hom s 5, KRT6A, K6A, KRT6D |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | KRT6A |
|---|---|
| Synonyms | K6A, KRT6D |
| Function | Epidermis-specific type I keratin involved in wound healing. Involved in the activation of follicular keratinocytes after wounding, while it does not play a major role in keratinocyte proliferation or migration. Participates in the regulation of epithelial migration by inhibiting the activity of SRC during wound repair. |
| Tissue Location | Expressed in the corneal epithelium (at protein level). |
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Provided below are standard protocols that you may find useful for product applications.
Background
The protein encoded by this gene is a member of thekeratin gene family. The type II cytokeratins consist of basic orneutral proteins which are arranged in pairs of heterotypic keratinchains coexpressed during differentiation of simple and stratifiedepithelial tissues. As many as six of this type II cytokeratin(KRT6) have been identified; the multiplicity of the genes isattributed to successive gene duplication events. The genes areexpressed with family members KRT16 and/or KRT17 in the filiformpapillae of the tongue, the stratified epithelial lining of oralmucosa and esophagus, the outer root sheath of hair follicles, andthe glandular epithelia. This KRT6 gene in particular encodes themost abundant isoform. Mutations in these genes have beenassociated with pachyonychia congenita. The type II cytokeratinsare clustered in a region of chromosome 12q12-q13. [provided byRefSeq].
References
Dereure, O. Ann Dermatol Venereol 137(5):423-424(2010)Trost, A., et al. Mech. Ageing Dev. 131(5):346-353(2010)Yang, L., et al. Zhonghua Yi Xue Yi Chuan Xue Za Zhi 27(1):66-68(2010)Millar, E.K., et al. J. Clin. Oncol. 27(28):4701-4708(2009)Bai, Z.L., et al. Zhonghua Yi Xue Yi Chuan Xue Za Zhi 26(5):514-517(2009)
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