|Other Names||Metabotropic glutamate receptor 7, mGluR7, GRM7, GPRC1G, MGLUR7|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity.|
|Cellular Location||Cell membrane; Multi-pass membrane protein.|
|Tissue Location||Expressed in many areas of the brain, especially in the cerebral cortex, hippocampus, and cerebellum Expression of GRM7 isoforms in non-neuronal tissues appears to be restricted to isoform 3 and isoform 4|
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L-glutamate is the major excitatory neurotransmitter inthe central nervous system, and it activates both ionotropic andmetabotropic glutamate receptors. Glutamatergic neurotransmissionis involved in most aspects of normal brain function and can beperturbed in many neuropathologic conditions. The metabotropicglutamate receptors are a family of G protein-coupled receptorsthat have been divided into three groups on the basis of sequencehomology, putative signal transduction mechanisms, andpharmacologic properties. Group I includes GRM1 and GRM5, and thesereceptors have been shown to activate phospholipase C. Group IIincludes GRM2 and GRM3, while Group III includes GRM4, GRM6, GRM7and GRM8. Group II and III receptors are linked to the inhibitionof the cyclic AMP cascade but differ in their agonistselectivities. Multiple transcript variants encoding differentisoforms have been found for this gene.
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Saus, E., et al. J Psychiatr Res 44(14):971-978(2010)Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Joslyn, G., et al. Alcohol. Clin. Exp. Res. 34(5):800-812(2010)Schulz, H.L., et al. Neurosci. Lett. 326(1):37-40(2002)
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