|Other Names||Coagulation factor IX, Christmas factor, Plasma thromboplastin component, PTC, Coagulation factor IXa light chain, Coagulation factor IXa heavy chain, F9|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Factor IX is a vitamin K-dependent plasma protein that participates in the intrinsic pathway of blood coagulation by converting factor X to its active form in the presence of Ca(2+) ions, phospholipids, and factor VIIIa.|
|Tissue Location||Detected in blood plasma (at protein level) (PubMed:3857619, PubMed:8295821, PubMed:2592373, PubMed:9169594, PubMed:19846852). Synthesized primarily in the liver and secreted in plasma.|
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This gene encodes vitamin K-dependent coagulation factorIX that circulates in the blood as an inactive zymogen. This factoris converted to an active form by factor XIa, which excises theactivation peptide and thus generates a heavy chain and a lightchain held together by one or more disulfide bonds. The role ofthis activated factor IX in the blood coagulation cascade is toactivate factor X to its active form through interactions with Ca+2ions, membrane phospholipids, and factor VIII. Alterations of thisgene, including point mutations, insertions and deletions, causefactor IX deficiency, which is a recessive X-linked disorder, alsocalled hemophilia B or Christmas disease.
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Yang, L., et al. J. Biol. Chem. 285(37):28488-28495(2010)Kao, C.Y., et al. Thromb. Haemost. 104(2):355-365(2010)Roberts, K.E., et al. Gastroenterology 139(1):130-139(2010)Arellano, A.R., et al. J. Thromb. Haemost. 8(5):1132-1134(2010)
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