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>   home   >   Products   >   Peptides   >   Blocking Peptides   >   F9 Antibody (Center) Blocking Peptide   

F9 Antibody (Center) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession P00740
Clone Names 100427196
Peptide ID 100427196
Additional Information
Gene ID 2158
Other Names Coagulation factor IX, Christmas factor, Plasma thromboplastin component, PTC, Coagulation factor IXa light chain, Coagulation factor IXa heavy chain, F9
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name F9
Function Factor IX is a vitamin K-dependent plasma protein that participates in the intrinsic pathway of blood coagulation by converting factor X to its active form in the presence of Ca(2+) ions, phospholipids, and factor VIIIa.
Cellular Location Secreted.
Tissue Location Synthesized primarily in the liver and secreted in plasma
Research Areas
Citations (0)

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Background

This gene encodes vitamin K-dependent coagulation factorIX that circulates in the blood as an inactive zymogen. This factoris converted to an active form by factor XIa, which excises theactivation peptide and thus generates a heavy chain and a lightchain held together by one or more disulfide bonds. The role ofthis activated factor IX in the blood coagulation cascade is toactivate factor X to its active form through interactions with Ca+2ions, membrane phospholipids, and factor VIII. Alterations of thisgene, including point mutations, insertions and deletions, causefactor IX deficiency, which is a recessive X-linked disorder, alsocalled hemophilia B or Christmas disease.

References

Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Yang, L., et al. J. Biol. Chem. 285(37):28488-28495(2010)Kao, C.Y., et al. Thromb. Haemost. 104(2):355-365(2010)Roberts, K.E., et al. Gastroenterology 139(1):130-139(2010)Arellano, A.R., et al. J. Thromb. Haemost. 8(5):1132-1134(2010)

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$ 80.00
Cat# BP16976c
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