|Other Names||Rhodopsin, Opsin-2, RHO, OPN2|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Photoreceptor required for image-forming vision at low light intensity (PubMed:8107847, PubMed:7846071). Required for photoreceptor cell viability after birth (PubMed:2215617, PubMed:12566452). Light-induced isomerization of the chromophore 11-cis-retinal to all-trans-retinal triggers a conformational change that activates signaling via G-proteins (PubMed:8107847, PubMed:28524165, PubMed:26200343, PubMed:28753425). Subsequent receptor phosphorylation mediates displacement of the bound G- protein alpha subunit by the arrestin SAG and terminates signaling (PubMed:28524165, PubMed:26200343).|
|Cellular Location||Membrane; Multi- pass membrane protein. Cell projection, cilium, photoreceptor outer segment. Note=Synthesized in the inner segment (IS) of rod photoreceptor cells before vectorial transport to disk membranes in the rod outer segment (OS) photosensory cilia.|
|Tissue Location||Rod shaped photoreceptor cells which mediate vision in dim light|
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Provided below are standard protocols that you may find useful for product applications.
Retinitis pigmentosa is an inherited progressive diseasewhich is a major cause of blindness in western communities. It canbe inherited as an autosomal dominant, autosomal recessive, orX-linked recessive disorder. In the autosomal dominant form,whichcomprises about 25% of total cases, approximately 30% of familieshave mutations in the gene encoding the rod photoreceptor-specificprotein rhodopsin. This is the transmembrane protein which, whenphotoexcited, initiates the visual transduction cascade. Defects inthis gene are also one of the causes of congenital stationary nightblindness.
Clark, G.R., et al. Ophthalmology 117(11):2169-2177(2010)Li, S., et al. Biochem. Biophys. Res. Commun. 401(1):42-47(2010)Pulagam, L.P., et al. J. Biol. Chem. 285(38):29446-29456(2010)Audo, I., et al. Arch. Ophthalmol. 128(8):1036-1045(2010)Audo, I., et al. Invest. Ophthalmol. Vis. Sci. 51(7):3687-3700(2010)
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