|Other Names||Kelch domain-containing protein 8B, KLHDC8B|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Involved in pinching off the separated nuclei at the cleavage furrow and in cytokinesis (PubMed:20107318). Required for mitotic integrity and maintenance of chromosomal stability. Protects cells against mitotic errors, centrosomal amplification, micronucleus formation and aneuploidy. Plays a key role of midbody function involving abscission of the daughter cells during cytokinesis and appropriate chromosomal and nuclear segregation into the daughter cells (PubMed:22988245, PubMed:23713010).|
|Cellular Location||Cytoplasm. Midbody Note=In mitotic cells, concentrates in the midbody of the cytoplasmic bridge linking daughter cells as they are about to separate during cytokinesis.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a protein which forms a distinctbeta-propeller protein structure of kelch domains allowing forprotein-protein interactions. Mutations in this gene have beenassociated with Hodgkin lymphoma.
Krem, M.M., et al. Cell Cycle 9(4):670-675(2010)Salipante, S.J., et al. Proc. Natl. Acad. Sci. U.S.A. 106(35):14920-14925(2009)Wan, D., et al. Proc. Natl. Acad. Sci. U.S.A. 101(44):15724-15729(2004)Adams, M.D., et al. Nat. Genet. 4(4):373-380(1993)
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