|Other Names||Signal-induced proliferation-associated protein 1, Sipa-1, GTPase-activating protein Spa-1, p130 SPA-1, SIPA1, SPA1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||GTPase activator for the nuclear Ras-related regulatory proteins Rap1 and Rap2 in vitro, converting it to the putatively inactive GDP-bound state.|
|Cellular Location||Nucleus. Cytoplasm, perinuclear region. Endomembrane system; Peripheral membrane protein. Note=Mostly localized in the perinuclear membraneous region|
|Tissue Location||Expressed in fetal as well as in adult tissues. Expressed abundantly in the lymphoid tissues such as thymus, spleen and peripheral blood lymphocytes and also shows a significant expression in the spinal cord|
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Provided below are standard protocols that you may find useful for product applications.
The product of this gene is a mitogen induced GTPaseactivating protein (GAP). It exhibits a specific GAP activity forRas-related regulatory proteins Rap1 and Rap2, but not for Ran orother small GTPases. This protein may also hamper mitogen-inducedcell cycle progression when abnormally or prematurely expressed. Itis localized to the perinuclear region. Two alternatively splicedvariants encoding the same isoform have been characterized to date.
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Brooks, R., et al. Gynecol. Oncol. 116(3):539-543(2010)Hosgood, H.D. III, et al. Occup Environ Med 66(12):848-853(2009)Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)Hsieh, S.M., et al. Breast Cancer Res. 11 (5), R75 (2009) :
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