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HNRNPA1 Antibody (C-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P09651 |
|---|---|
| Clone Names | 100430082 |
| Gene ID | 3178 |
|---|---|
| Other Names | Heterogeneous nuclear ribonucleoprotein A1, hnRNP A1, Helix-destabilizing protein, Single-strand RNA-binding protein, hnRNP core protein A1, Heterogeneous nuclear ribonucleoprotein A1, N-terminally processed, HNRNPA1, HNRPA1 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | HNRNPA1 |
|---|---|
| Synonyms | HNRPA1 |
| Function | Involved in the packaging of pre-mRNA into hnRNP particles, transport of poly(A) mRNA from the nucleus to the cytoplasm and modulation of splice site selection (PubMed:17371836). Plays a role in the splicing of pyruvate kinase PKM by binding repressively to sequences flanking PKM exon 9, inhibiting exon 9 inclusion and resulting in exon 10 inclusion and production of the PKM M2 isoform (PubMed:20010808). Binds to the IRES and thereby inhibits the translation of the apoptosis protease activating factor APAF1 (PubMed:31498791). May bind to specific miRNA hairpins (PubMed:28431233). |
| Cellular Location | Nucleus. Cytoplasm Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs. Shuttles continuously between the nucleus and the cytoplasm along with mRNA. Component of ribonucleosomes (PubMed:17289661) Nucleus. Note=(Microbial infection) SARS coronavirus-2/SARS-CoV-2 ORF6 protein increases accumulation to the nucleus. |
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Background
This gene belongs to the A/B subfamily of ubiquitouslyexpressed heterogeneous nuclear ribonucleoproteins (hnRNPs). ThehnRNPs are RNA binding proteins and they complex with heterogeneousnuclear RNA (hnRNA). These proteins are associated with pre-mRNAsin the nucleus and appear to influence pre-mRNA processing andother aspects of mRNA metabolism and transport. While all of thehnRNPs are present in the nucleus, some seem to shuttle between thenucleus and the cytoplasm. The hnRNP proteins have distinct nucleicacid binding properties. The protein encoded by this gene has tworepeats of quasi-RRM domains that bind to RNAs. It is one of themost abundant core proteins of hnRNP complexes and it is localizedto the nucleoplasm. This protein, along with other hnRNP proteins,is exported from the nucleus, probably bound to mRNA, and isimmediately re-imported. Its M9 domain acts as both a nuclearlocalization and nuclear export signal. The encoded protein isinvolved in the packaging of pre-mRNA into hnRNP particles,transport of poly A+ mRNA from the nucleus to the cytoplasm, andmay modulate splice site selection. It is also thought have aprimary role in the formation of specific myometrial proteinspecies in parturition. Multiple alternatively spliced transcriptvariants have been found for this gene but only two transcripts arefully described. These variants have multiple alternativetranscription initiation sites and multiple polyA sites. [providedby RefSeq].
References
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Michlewski, G., et al. Nat. Struct. Mol. Biol. 17(8):1011-1018(2010)Clower, C.V., et al. Proc. Natl. Acad. Sci. U.S.A. 107(5):1894-1899(2010)David, C.J., et al. Nature 463(7279):364-368(2010)Fisette, J.F., et al. RNA 16(1):228-238(2010)
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