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HEYL Antibody (N-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q9NQ87 |
|---|---|
| Clone Names | 100430172 |
| Gene ID | 26508 |
|---|---|
| Other Names | Hairy/enhancer-of-split related with YRPW motif-like protein, hHeyL, Class B basic helix-loop-helix protein 33, bHLHb33, Hairy-related transcription factor 3, HRT-3, hHRT3, HEYL, BHLHB33, HRT3 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | HEYL |
|---|---|
| Synonyms | BHLHB33, HRT3 |
| Function | Downstream effector of Notch signaling which may be required for cardiovascular development (By similarity). Transcriptional repressor which binds preferentially to the canonical E box sequence 5'-CACGTG-3' (By similarity). Represses transcription by the cardiac transcriptional activators GATA4 and GATA6. |
| Cellular Location | Nucleus {ECO:0000255|PROSITE-ProRule:PRU00380, ECO:0000255|PROSITE-ProRule:PRU00981} |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a member of the hairy and enhancer ofsplit-related (HESR) family of basic helix-loop-helix (bHLH)-typetranscription factors. The sequence of the encoded protein containsa conserved bHLH and orange domain, but its YRPW motif has divergedfrom other HESR family members. It is thought to be an effector ofNotch signaling and a regulator of cell fate decisions.Alternatively spliced transcript variants have been found, buttheir biological validity has not been determined. [provided byRefSeq].
References
Kokubo, H., et al. Trends Cardiovasc. Med. 15(5):190-194(2005)Colland, F., et al. Genome Res. 14(7):1324-1332(2004)Iso, T., et al. J. Cell. Physiol. 194(3):237-255(2003)Nakagawa, O., et al. Proc. Natl. Acad. Sci. U.S.A. 97(25):13655-13660(2000)Firulli, B.A., et al. J. Biol. Chem. 275(43):33567-33573(2000)
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