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>   home   >   Products   >   Peptides   >   Blocking Peptides   >   HEYL Antibody (N-term) Blocking Peptide   

HEYL Antibody (N-term) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession Q9NQ87
Clone Names 100430172
Peptide ID 100430172
Additional Information
Gene ID 26508
Other Names Hairy/enhancer-of-split related with YRPW motif-like protein, hHeyL, Class B basic helix-loop-helix protein 33, bHLHb33, Hairy-related transcription factor 3, HRT-3, hHRT3, HEYL, BHLHB33, HRT3
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name HEYL
Synonyms BHLHB33, HRT3
Function Downstream effector of Notch signaling which may be required for cardiovascular development (By similarity). Transcriptional repressor which binds preferentially to the canonical E box sequence 5'-CACGTG-3' (By similarity). Represses transcription by the cardiac transcriptional activators GATA4 and GATA6.
Cellular Location Nucleus {ECO:0000255|PROSITE- ProRule:PRU00380, ECO:0000255|PROSITE-ProRule:PRU00981}
Research Areas
Citations (0)

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Background

This gene encodes a member of the hairy and enhancer ofsplit-related (HESR) family of basic helix-loop-helix (bHLH)-typetranscription factors. The sequence of the encoded protein containsa conserved bHLH and orange domain, but its YRPW motif has divergedfrom other HESR family members. It is thought to be an effector ofNotch signaling and a regulator of cell fate decisions.Alternatively spliced transcript variants have been found, buttheir biological validity has not been determined. [provided byRefSeq].

References

Kokubo, H., et al. Trends Cardiovasc. Med. 15(5):190-194(2005)Colland, F., et al. Genome Res. 14(7):1324-1332(2004)Iso, T., et al. J. Cell. Physiol. 194(3):237-255(2003)Nakagawa, O., et al. Proc. Natl. Acad. Sci. U.S.A. 97(25):13655-13660(2000)Firulli, B.A., et al. J. Biol. Chem. 275(43):33567-33573(2000)

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$ 80.00
Cat# BP16997a
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