|Other Names||Zinc finger and BTB domain-containing protein 7B, Krueppel-related zinc finger protein cKrox, hcKrox, T-helper-inducing POZ/Krueppel-like factor, Zinc finger and BTB domain-containing protein 15, Zinc finger protein 67 homolog, Zfp-67, Zinc finger protein 857B, Zinc finger protein Th-POK, ZBTB7B, ZBTB15, ZFP67, ZNF857B|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Synonyms||ZBTB15, ZFP67, ZNF857B|
|Function||Transcription regulator that acts as a key regulator of lineage commitment of immature T-cell precursors. Necessary and sufficient for commitment of CD4 lineage, while its absence causes CD8 commitment. Development of immature T-cell precursors (thymocytes) to either the CD4 helper or CD8 killer T-cell lineages correlates precisely with their T-cell receptor specificity for major histocompatibility complex class II or class I molecules, respectively. Transcriptional repressor of the collagen COL1A1 and COL1A2 genes. May also function as a repressor of fibronectin and possibly other extracellular matrix genes (By similarity).|
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Provided below are standard protocols that you may find useful for product applications.
ZFP67 is an early growth response gene that encodes a zincfinger-containing transcription factor that binds to the promoterregions of type I collagen genes (e.g., COL1A1; MIM 120150) and hasa role in development.
Zhang, M., et al. J. Immunol. 185(7):3960-3969(2010)Yerges, L.M., et al. J. Bone Miner. Res. 24(12):2039-2049(2009)Egawa, T. J. Cell. Biochem. 107(6):1037-1045(2009)Tokunaga, T., et al. Autoimmunity 42(8):653-660(2009)Renard, E., et al. J. Cell. Mol. Med. 12 (6B), 2836-2847 (2008) :
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