|Other Names||Vasoactive intestinal polypeptide receptor 2, VIP-R-2, Helodermin-preferring VIP receptor, Pituitary adenylate cyclase-activating polypeptide type III receptor, PACAP type III receptor, PACAP-R-3, PACAP-R3, VPAC2, VIPR2, VIP2R|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||This is a receptor for VIP as well as PACAP-38 and -27, the activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Can be coupled to phospholipase C.|
|Cellular Location||Cell membrane; Multi-pass membrane protein.|
|Tissue Location||Expressed in CD4+ T-cells, but not in CD8+ T- cells. Expressed in the T-cell lines Jurkat, Peer, MOLT-4, HSB, YT and SUP-T1, but not in the T-cell lines HARRIS and HuT 78|
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Provided below are standard protocols that you may find useful for product applications.
Vasoactive intestinal peptide (VIP; MIM 192320) andpituitary adenylate cyclase activating polypeptide (PACAP; MIM102980) are homologous peptides that function as neurotransmittersand neuroendocrine hormones. While the receptors for VIP and PACAPshare homology, they differ in their substrate specificities andexpression patterns. See VIPR1 (MIM 192321) and ADCYAP1R1(MIM102981).
Kovanen, L., et al. Alcohol Alcohol. 45(4):303-311(2010)Kellogg, D.L. Jr., et al. J. Appl. Physiol. 109(1):95-100(2010)Liu, Y.J., et al. Obesity (Silver Spring) (2010) In press :Yoshida, T., et al. Int. J. Mol. Med. 25(4):649-656(2010)Sjoholm, L.K., et al. J Circadian Rhythms 8, 1 (2010) :
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