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HRH3 Antibody (Center) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession Q9Y5N1
Peptide ID 44181
Additional Information
Gene ID 11255
Other Names Histamine H3 receptor, H3R, HH3R, G-protein coupled receptor 97, HRH3, GPCR97
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name HRH3
Synonyms GPCR97
Function The H3 subclass of histamine receptors could mediate the histamine signals in CNS and peripheral nervous system. Signals through the inhibition of adenylate cyclase and displays high constitutive activity (spontaneous activity in the absence of agonist). Agonist stimulation of isoform 3 neither modified adenylate cyclase activity nor induced intracellular calcium mobilization.
Cellular Location Cell membrane; Multi-pass membrane protein.
Tissue Location Expressed predominantly in the CNS, with the greatest expression in the thalamus and caudate nucleus. The various isoforms are mainly coexpressed in brain, but their relative expression level varies in a region-specific manner Isoform 3 and isoform 7 are highly expressed in the thalamus, caudate nucleus and cerebellum while isoform 5 and isoform 6 show a poor expression. Isoform 5 and isoform 6 show a high expression in the amygdala, substantia nigra, cerebral cortex and hypothalamus. Isoform 7 is not found in hypothalamus or substantia nigra
Research Areas
Citations (0)

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HRH3 is a ubiquitous messenger molecule released from mast cells, enterochromaffin-like cells, and neurons. Its various actions are mediated by histamine receptors H1, H2, H3 and H4. This gene encodes one of the histamine receptors (H3) which belongs to the family 1 of G protein-coupled receptors. It is an integral membrane protein and can regulate neurotransmitter release. This receptor can also increase voltage-dependent calcium current in smooth muscles and innervates the blood vessels and the heart in cardiovascular system.


Ferreira, M.A., et al. Allergy 64(11):1623-1628(2009)Francis, H., et al. Mol. Cancer Res. 7(10):1704-1713(2009)Jin, C.Y., et al. Br. J. Pharmacol. 157(1):118-129(2009)

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$ 80.00
Cat# BP1700c
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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