|Other Names||CX3C chemokine receptor 1, C-X3-C CKR-1, CX3CR1, Beta chemokine receptor-like 1, CMK-BRL-1, CMK-BRL1, Fractalkine receptor, G-protein coupled receptor 13, V28, CX3CR1, CMKBRL1, GPR13|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Receptor for the CX3C chemokine fractalkine (CX3CL1); binds to CX3CL1 and mediates both its adhesive and migratory functions (PubMed:9390561, PubMed:23125415). Acts as coreceptor with CD4 for HIV-1 virus envelope protein (in vitro) (PubMed:9726990). Isoform 2 and isoform 3 seem to be more potent HIV-1 coreceptors than isoform 1 (PubMed:14607932).|
|Cellular Location||Cell membrane; Multi-pass membrane protein|
|Tissue Location||Expressed in lymphoid and neural tissues.|
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Fractalkine is a transmembrane protein and chemokineinvolved in the adhesion and migration of leukocytes. The proteinencoded by this gene is a receptor for fractalkine. The encodedprotein also is a coreceptor for HIV-1, and some variations in thisgene lead to increased susceptibility to HIV-1 infection and rapidprogression to AIDS. Four transcript variants encoding twodifferent isoforms have been found for this gene. [provided byRefSeq].
Karlmark, K.R., et al. Hepatology 52(5):1769-1782(2010)Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Yang, X., et al. Br J Ophthalmol 94(9):1211-1214(2010)Sezgin, E., et al. J. Acquir. Immune Defic. Syndr. 54(4):343-351(2010)Staniland, A.A., et al. J. Neurochem. 114(4):1143-1157(2010)
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