|Other Names||Interleukin-23 receptor, IL-23 receptor, IL-23R, IL23R|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Associates with IL12RB1 to form the interleukin-23 receptor. Binds IL23 and mediates T-cells, NK cells and possibly certain macrophage/myeloid cells stimulation probably through activation of the Jak-Stat signaling cascade. IL23 functions in innate and adaptive immunity and may participate in acute response to infection in peripheral tissues. IL23 may be responsible for autoimmune inflammatory diseases and be important for tumorigenesis.|
|Cellular Location||Cell membrane; Single-pass type I membrane protein|
|Tissue Location||Expressed by monocytes, Th1, Th0, NK and dendritic cells. Isoform 1 is specifically expressed in NK cells|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is a subunit of thereceptor for IL23A/IL23. This protein pairs with the receptormolecule IL12RB1/IL12Rbeta1, and both are required for IL23Asignaling. This protein associates constitutively with Janus kinase2 (JAK2), and also binds to transcription activator STAT3 in aligand-dependent manner.
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Chen, J., et al. Mol. Carcinog. 49(10):862-868(2010)Mizuki, N., et al. Nat. Genet. 42(8):703-706(2010)Remmers, E.F., et al. Nat. Genet. 42(8):698-702(2010)Elmaagacli, A.H., et al. Bone Marrow Transplant. (2010) In press :
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