|Other Names||Paired box protein Pax-2, PAX2|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Transcription factor that may have a role in kidney cell differentiation (PubMed:24676634). Has a critical role in the development of the urogenital tract, the eyes, and the CNS.|
|Tissue Location||Expressed in primitive cells of the kidney, ureter, eye, ear and central nervous system|
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PAX2 encodes paired box gene 2, one of many humanhomologues of the Drosophila melanogaster gene prd. The centralfeature of this transcription factor gene family is the conservedDNA-binding paired box domain. PAX2 is believed to be a target oftranscriptional supression by the tumor supressor gene WT1.Mutations within PAX2 have been shown to result in optic nervecolobomas and renal hypoplasia. Alternative splicing of this generesults in multiple transcript variants.
Monte, N.M., et al. Cancer Res. 70(15):6225-6232(2010)Ozcan, A., et al. Arch. Pathol. Lab. Med. 134(8):1121-1129(2010)Quick, C.M., et al. Hum. Pathol. 41(8):1145-1149(2010)Martinovic-Bouriel, J., et al. Am. J. Med. Genet. A 152A (4), 830-835 (2010) :Rabban, J.T., et al. Am. J. Surg. Pathol. 34(2):137-146(2010)
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