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>   home   >   Products   >   Peptides   >   Blocking Peptides   >   RCOR1 Antibody (N-term) Blocking Peptide   

RCOR1 Antibody (N-term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession Q9UKL0
Clone Names 100517001
Peptide ID 100517001
Additional Information
Gene ID 23186
Other Names REST corepressor 1, Protein CoREST, RCOR1, KIAA0071, RCOR
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name RCOR1
Synonyms KIAA0071, RCOR
Function Essential component of the BHC complex, a corepressor complex that represses transcription of neuron-specific genes in non-neuronal cells. The BHC complex is recruited at RE1/NRSE sites by REST and acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier. In the BHC complex, it serves as a molecular beacon for the recruitment of molecular machinery, including MeCP2 and SUV39H1, that imposes silencing across a chromosomal interval. Plays a central role in demethylation of Lys-4 of histone H3 by promoting demethylase activity of KDM1A on core histones and nucleosomal substrates. It also protects KDM1A from the proteasome. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development and controls hematopoietic differentiation.
Cellular Location Nucleus {ECO:0000255|PROSITE- ProRule:PRU00512, ECO:0000255|PROSITE-ProRule:PRU00624, ECO:0000269|PubMed:10734093, ECO:0000269|PubMed:15897453} Note=Upon infection by HSV-1, it is partially translocated into the cytoplasm in an HSV-1-dependent manner
Tissue Location Ubiquitously expressed.
Research Areas
Citations (0)

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The RCOR gene encodes a functional corepressor requiredfor regulation of neural-specific gene expression.[supplied byOMIM].


Xiao, J., et al. J. Orthop. Res. 28(12):1569-1575(2010)Everett, R.D. J. Virol. 84(7):3695-3698(2010)Das, C., et al. J. Mol. Biol. 397(1):1-12(2010)Laurent, B., et al. Stem Cells 27(9):2153-2162(2009)Wang, Y., et al. Cell 138(4):660-672(2009)

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$ 80.00
Cat# BP17018a
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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