|Other Names||Free fatty acid receptor 4, G-protein coupled receptor 120, G-protein coupled receptor 129, G-protein coupled receptor GT01, G-protein coupled receptor PGR4, Omega-3 fatty acid receptor 1, FFAR4, GPR120, GPR129, O3FAR1, PGR4|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Synonyms||GPR120, GPR129, O3FAR1, PGR4|
|Function||Receptor for medium and long-chain free fatty acids (FFAs). Signals via a G(q)/G(11)-coupled pathway. Acts as a receptor for omega-3 fatty acids and mediates robust anti- inflammatory effects, particularly in macrophages and fat cells. The anti-inflammatory effects involve inhibition of TAK1 through a beta-arrestin 2 (ARRB2)/TAB1-dependent effect, but independent of the G(q)/G(11)-coupled pathway. Mediates potent insulin sensitizing and antidiabetic effects by repressing macrophage- induced tissue inflammation. May mediate the taste of fatty acids. Mediates FFA-induced inhibition of apoptosis in enteroendocrine cells. May play a role in the regulation of adipocyte development and differentiation.|
|Cellular Location||Cell membrane; Multi-pass membrane protein. Note=Colocalized with ARRB2 following DHA treatment.|
|Tissue Location||Abundant expression in the intestinal tract. Highly expressed in adipose tissue, small intestine and pancreas|
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Provided below are standard protocols that you may find useful for product applications.
GPR120 is a member of the rhodopsin family of Gprotein-coupled receptors (GPRs) (Fredriksson et al., 2003 [PubMed14623098]).
Shimada, M., et al. Hum. Genet. 128(4):433-441(2010)Burns, R.N., et al. Biochem. Biophys. Res. Commun. 396(4):1030-1035(2010)Moore, K., et al. Comp. Biochem. Physiol. B, Biochem. Mol. Biol. 154(4):419-426(2009)Oh, J.H., et al. Mamm. Genome 16(12):942-954(2005)Hirasawa, A., et al. Nat. Med. 11(1):90-94(2005)
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