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FCN1 Antibody (C-term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession O00602
Clone Names 100528095
Peptide ID 100528095
Additional Information
Gene ID 2219
Other Names Ficolin-1, Collagen/fibrinogen domain-containing protein 1, Ficolin-A, Ficolin-alpha, M-ficolin, FCN1, FCNM
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name FCN1
Synonyms FCNM
Function Extracellular lectin functioning as a pattern- recognition receptor in innate immunity. Binds the sugar moieties of pathogen-associated molecular patterns (PAMPs) displayed on microbes and activates the lectin pathway of the complement system. May also activate monocytes through a G protein-coupled receptor, FFAR2, inducing the secretion of interleukin-8/IL-8 (PubMed:21037097). Binds preferentially to 9-O-acetylated 2-6- linked sialic acid derivatives and to various glycans containing sialic acid engaged in a 2-3 linkage.
Cellular Location Secreted. Cell membrane; Peripheral membrane protein; Extracellular side Note=Found on the monocyte and granulocyte surface (PubMed:20400674)
Tissue Location Peripheral blood leukocytes, monocytes and granulocytes. Also detected in spleen, lung, and thymus, may be due to the presence of tissue macrophages or trapped blood in these tissues. Not detected on lymphocytes
Research Areas
Citations (0)

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The ficolin family of proteins are characterized by thepresence of a leader peptide, a short N-terminal segment, followedby a collagen-like region, and a C-terminal fibrinogen-like domain.The collagen-like and the fibrinogen-like domains are also foundseparately in other proteins such as complement protein C1q, C-typelectins known as collectins, and tenascins. However, all theseproteins recognize different targets, and are functionallydistinct. Ficolin 1 encoded by FCN1 is predominantly expressed inthe peripheral blood leukocytes, and has been postulated tofunction as a plasma protein with elastin-binding activity.


Honore, C., et al. J. Leukoc. Biol. 88(1):145-158(2010)Davila, S., et al. Genes Immun. 11(3):232-238(2010)Gout, E., et al. J. Biol. Chem. 285(9):6612-6622(2010)Wittenborn, T., et al. J Innate Immun 2(2):167-180(2010)Tanio, M., et al. Mol. Immunol. 47 (2-3), 215-221 (2009) :

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$ 80.00
Cat# BP17029b
Availability: In Stock
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