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> home > Products > Peptides > Biological Process > Organ Development > ESR2 Antibody (Center) Blocking Peptide
ESR2 Antibody (Center) Blocking PeptideSynthetic peptide
| Country | United States
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| Catalog # | Size | Availability | Price | |
| BP1702c | 0.1 mg 400 ul | In Stock | $ 45.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
- Specification
- Citiations : 0
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- Backgrounds
ESR2 Antibody (Center) Blocking Peptide - Product info | |
| Primary Accession | Q92731 |
| Clone Names | 80311219 |
| Calculated MW | 59216 Da |
ESR2 Antibody (Center) Blocking Peptide - Additional info | |
| Gene ID 2100 | |
| Target/Specificity The synthetic peptide sequence used to generate the antibody AP1702c was selected from the Center region of human ESR2. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. | |
| Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml. | |
| Storage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. | |
| Precautions This product is for research use only. Not for use in diagnostic or therapeutic procedures. | |
ESR2 Antibody (Center) Blocking Peptide - Protein Information | |
| Name ESR2 | |
| Synonyms ESTRB, NR3A2 | |
| Function Nuclear hormone receptor. Binds estrogens with an affinity similar to that of ESR1, and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner. Isoform beta-cx lacks ligand binding ability and has no or only very low ere binding activity resulting in the loss of ligand-dependent transactivation ability. DNA- binding by ESR1 and ESR2 is rapidly lost at 37 degrees Celsius in the absence of ligand while in the presence of 17 beta-estradiol and 4-hydroxy-tamoxifen loss in DNA-binding at elevated temperature is more gradual | |
| Cellular Location Nucleus. | |
| Tissue Location Isoform beta-1 is expressed in testis and ovary, and at a lower level in heart, brain, placenta, liver, skeletal muscle, spleen, thymus, prostate, colon, bone marrow, mammary gland and uterus. Also found in uterine bone, breast, and ovarian tumor cell lines, but not in colon and liver tumors Isoform beta-2 is expressed in spleen, thymus, testis and ovary and at a lower level in skeletal muscle, prostate, colon, small intestine, leukocytes, bone marrow, mammary gland and uterus Isoform beta-3 is found in testis. Isoform beta-4 is expressed in testis, and at a lower level in spleen, thymus, ovary, mammary gland and uterus. Isoform beta-5 is expressed in testis, placenta, skeletal muscle, spleen and leukocytes, and at a lower level in heart, lung, liver, kidney, pancreas, thymus, prostate, colon, small intestine, bone marrow, mammary gland and uterus. Not expressed in brain | |
ESR2 Antibody (Center) Blocking Peptide - Related products
AP1702c: ESR2 Antibody (Center)
BP1702c: ESR2 Antibody (Center) Blocking Peptide
ESR2 Antibody (Center) Blocking Peptide - Research Areas
PeptidesBiological ProcessOrgan DevelopmentMetabolic ProcessPrimary Metabolic ProcessCellular Metabolic ProcessCellular ProcessPositive Regulation Of Biological ProcessPositive Regulation Of Cellular ProcessRegulation Of Cell DeathRegulation Of Programmed Cell DeathResponse To Organic SubstanceRegulation Of ApoptosisPositive Regulation Of Cellular Metabolic ProcessPositive Regulation Of Metabolic ProcessPositive Regulation Of Macromolecule Metabolic ProcessNegative Regulation Of Cellular ProcessNegative Regulation Of Biological ProcessResponse To Chemical StimulusPositive Regulation Of Biosynthetic ProcessResponse To Endogenous StimulusPositive Regulation Of Cellular Biosynthetic ProcessSystem DevelopmentMacromolecule Metabolic ProcessIntracellular Signaling CascadeMulticellular Organismal DevelopmentPositive Regulation Of Macromolecule Biosynthetic ProcessAnatomical Structure DevelopmentRegulation Of Cell ProliferationResponse To Hormone Stimulus
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Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
ESR2 is a nuclear hormone receptor. The protein binds estrogens with an affinity similar to that of ESR1, and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner.
REFERENCES
Chen H., Lin R.J.Cell 90:569-580(1997)Caira F., Antonson P.J. Biol. Chem. 275:5308-5317(2000)Bu H., Kashireddy P.Biochem. Biophys. Res. Commun. 317:54-59(2004)
