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ERVWE1 Antibody (C-term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession Q9UQF0
Clone Names 100617161
Peptide ID 100617161
Additional Information
Gene ID 30816
Other Names Syncytin-1, Endogenous retrovirus group W member 1, Env-W, Envelope polyprotein gPr73, Enverin, HERV-7q Envelope protein, HERV-W envelope protein, HERV-W_7q212 provirus ancestral Env polyprotein, Syncytin, Surface protein, SU, gp50, Transmembrane protein, TM, gp24, ERVW-1, ERVWE1
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name ERVW-1
Synonyms ERVWE1
Function This endogenous retroviral envelope protein has retained its original fusogenic properties and participates in trophoblast fusion and the formation of a syncytium during placenta morphogenesis. May induce fusion through binding of SLC1A4 and SLC1A5 (PubMed:10708449, PubMed:12050356, PubMed:23492904).
Cellular Location Transmembrane protein: Cell membrane; Single-pass type I membrane protein Syncytin-1: Virion.
Tissue Location Expressed at higher level in placental syncytiotrophoblast. Expressed at intermediate level in testis Seems also to be found at low level in adrenal tissue, bone marrow, breast, colon, kidney, ovary, prostate, skin, spleen, thymus, thyroid, brain and trachea. Both mRNA and protein levels are significantly increased in the brain of individuals with multiple sclerosis, particularly in astrocytes and microglia
Research Areas
Citations (0)

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Many different human endogenous retrovirus (HERV) familiesare expressed in normal placental tissue at high levels, suggestingthat HERVs are functionally important in reproduction. This gene ispart of an HERV provirus on chromosome 7 that has inactivatingmutations in the gag and pol genes. This gene is the envelopeglycoprotein gene which appears to have been selectively preserved.The gene's protein product is expressed in the placentalsyncytiotrophoblast and is involved in fusion of thecytotrophoblast cells to form the syncytial layer of the placenta.The protein has the characteristics of a typical retroviralenvelope protein, including a furin cleavage site that separatesthe surface (SU) and transmembrane (TM) proteins which form aheterodimer. Alternatively spliced transcript variants encoding thesame protein have been found for this gene.


Zhao, J., et al. BMC Med. Genet. 11, 96 (2010) :Oppelt, P., et al. Gynecol. Endocrinol. 25(11):741-747(2009)Gimenez, J., et al. DNA Res. 16(4):195-211(2009)Larsen, J.M., et al. Cancer Lett. 280(1):44-49(2009)Noorali, S., et al. Appl. Immunohistochem. Mol. Morphol. 17(4):319-328(2009)

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$ 80.00
Cat# BP17034b
Availability: In Stock
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