ERVWE1 Antibody (C-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q9UQF0 |
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Clone Names | 100617161 |
Gene ID | 30816 |
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Other Names | Syncytin-1, Endogenous retrovirus group W member 1, Env-W, Envelope polyprotein gPr73, Enverin, HERV-7q Envelope protein, HERV-W envelope protein, HERV-W_7q212 provirus ancestral Env polyprotein, Syncytin, Surface protein, SU, gp50, Transmembrane protein, TM, gp24, ERVW-1, ERVWE1 |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | ERVW-1 |
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Synonyms | ERVWE1 |
Function | This endogenous retroviral envelope protein has retained its original fusogenic properties and participates in trophoblast fusion and the formation of a syncytium during placenta morphogenesis. May induce fusion through binding of SLC1A4 and SLC1A5 (PubMed:10708449, PubMed:12050356, PubMed:23492904). |
Cellular Location | [Surface protein]: Cell membrane; Peripheral membrane protein. Note=The surface protein is not anchored to the membrane, but localizes to the extracellular surface through its binding to TM. [Syncytin-1]: Virion. |
Tissue Location | Expressed at higher level in placental syncytiotrophoblast. Expressed at intermediate level in testis. Seems also to be found at low level in adrenal tissue, bone marrow, breast, colon, kidney, ovary, prostate, skin, spleen, thymus, thyroid, brain and trachea. Both mRNA and protein levels are significantly increased in the brain of individuals with multiple sclerosis, particularly in astrocytes and microglia. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Many different human endogenous retrovirus (HERV) familiesare expressed in normal placental tissue at high levels, suggestingthat HERVs are functionally important in reproduction. This gene ispart of an HERV provirus on chromosome 7 that has inactivatingmutations in the gag and pol genes. This gene is the envelopeglycoprotein gene which appears to have been selectively preserved.The gene's protein product is expressed in the placentalsyncytiotrophoblast and is involved in fusion of thecytotrophoblast cells to form the syncytial layer of the placenta.The protein has the characteristics of a typical retroviralenvelope protein, including a furin cleavage site that separatesthe surface (SU) and transmembrane (TM) proteins which form aheterodimer. Alternatively spliced transcript variants encoding thesame protein have been found for this gene.
References
Zhao, J., et al. BMC Med. Genet. 11, 96 (2010) :Oppelt, P., et al. Gynecol. Endocrinol. 25(11):741-747(2009)Gimenez, J., et al. DNA Res. 16(4):195-211(2009)Larsen, J.M., et al. Cancer Lett. 280(1):44-49(2009)Noorali, S., et al. Appl. Immunohistochem. Mol. Morphol. 17(4):319-328(2009)
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