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HRH4 Antibody (Center) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q9H3N8 |
|---|---|
| Clone Names | 100617163 |
| Gene ID | 59340 |
|---|---|
| Other Names | Histamine H4 receptor, H4R, HH4R, AXOR35, G-protein coupled receptor 105, GPRv53, Pfi-013, SP9144, HRH4, GPCR105 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | HRH4 |
|---|---|
| Synonyms | GPCR105 |
| Function | The H4 subclass of histamine receptors could mediate the histamine signals in peripheral tissues. Displays a significant level of constitutive activity (spontaneous activity in the absence of agonist). |
| Cellular Location | Cell membrane; Multi-pass membrane protein. |
| Tissue Location | Expressed primarily in the bone marrow and eosinophils. Shows preferential distribution in cells of immunological relevance such as T-cells, dendritic cells, monocytes, mast cells, neutrophils. Also expressed in a wide variety of peripheral tissues, including the heart, kidney, liver, lung, pancreas, skeletal muscle, prostate, small intestine, spleen, testis, colon, fetal liver and lymph node. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Histamine is a ubiquitous messenger molecule released frommast cells, enterochromaffin-like cells, and neurons. Its variousactions are mediated by a family of histamine receptors, which area subset of the G-protein coupled receptor superfamily. This geneencodes a histamine receptor that is predominantly expressed inhaematopoietic cells. The protein is thought to play a role ininflammation and allergy reponses. Multiple transcript variantsencoding different isoforms have been found for this gene.
References
Yu, B., et al. Br. J. Dermatol. 163(5):935-940(2010)Gschwandtner, M., et al. Allergy 65(7):840-849(2010)Yu, B., et al. Br. J. Dermatol. 162(5):1038-1043(2010)Davila, S., et al. Genes Immun. 11(3):232-238(2010)Smits, R.A., et al. J. Med. Chem. 53(6):2390-2400(2010)
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