|Other Names||DNA-directed RNA polymerases I, II, and III subunit RPABC2, RNA polymerases I, II, and III subunit ABC2, DNA-directed RNA polymerase II subunit F, DNA-directed RNA polymerases I, II, and III 144 kDa polypeptide, RPABC144, RPB144, RPB6 homolog, RPC15, POLR2F, POLRF|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||DNA-dependent RNA polymerases catalyze the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II, and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. Pol II is the central component of the basal RNA polymerase II transcription machinery. Pols are composed of mobile elements that move relative to each other. In Pol II, POLR2F/RPB6 is part of the clamp element and together with parts of RPB1 and RPB2 forms a pocket to which the RPB4-RPB7 subcomplex binds (By similarity).|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes the sixth largest subunit of RNApolymerase II, the polymerase responsible for synthesizingmessenger RNA in eukaryotes, that is also shared by the other twoDNA-directed RNA polymerases. In yeast, this polymerase subunit, incombination with at least two other subunits, forms a structurethat stabilizes the transcribing polymerase on the DNA template.
Michiels, S., et al. Carcinogenesis 30(5):763-768(2009)Antonacopoulou, A.G., et al. Anticancer Res. 28 (2B), 1221-1227 (2008) :Zhou, M., et al. Proc. Natl. Acad. Sci. U.S.A. 100(22):12666-12671(2003)Kaehlcke, K., et al. Mol. Cell 12(1):167-176(2003)Jones, E., et al. Exp. Cell Res. 254(1):163-172(2000)
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